Definitions for ketamine
This page provides all possible meanings and translations of the word ketamine
ketamine, ketamine hydrochloride, Ketalar(noun)
a general anesthetic and tranquilizer (not a barbiturate) that is administered intravenously or intramuscularly; used mainly by veterinarians or for minor surgery with geriatric or pediatric patients; taken in large doses it causes hallucinations similar to those associated with the use of PCP
a pain-killing drug and anaesthetic
Ketamine is a drug used in human and veterinary medicine, primarily for the induction and maintenance of general anesthesia, usually in combination with a sedative. Other uses include sedation in intensive care, analgesia, and treatment of bronchospasm. Ketamine has a wide range of effects in humans, including analgesia, anesthesia, hallucinations, elevated blood pressure, and bronchodilation. Like other drugs of its class such as tiletamine and phencyclidine, it induces a state referred to as "dissociative anesthesia" and is used as a recreational drug. Ketamine has been shown to be effective in treating depression in patients with bipolar disorder who have not responded to antidepressants. In persons with major depressive disorder, it produces a rapid antidepressant effect, acting within two hours as opposed to the several weeks taken by typical antidepressants to work. Its hydrochloride salt is sold as Ketanest, Ketaset, and Ketalar. Pharmacologically, ketamine is classified as an NMDA receptor antagonist. At high, fully anesthetic level doses, ketamine has also been found to bind to μ-opioid receptors type 2 in cultured human neuroblastoma cells – however, without agonist activity – and to sigma receptors in rats. Also, ketamine interacts with muscarinic receptors, descending monoaminergic pain pathways and voltage-gated calcium channels.
U.S. National Library of Medicine
A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
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