What does homogentisate 1,2-dioxygenase mean?
Definitions for homogentisate 1,2-dioxygenase
ho·mogen·ti·sate 1,2-dioxy·ge·nase
This dictionary definitions page includes all the possible meanings, example usage and translations of the word homogentisate 1,2-dioxygenase.
Wikipedia
Homogentisate 1,2-dioxygenase
Homogentisate 1,2-dioxygenase (homogentisic acid oxidase, homogentisate oxidase, homogentisicase) is an enzyme which catalyzes the conversion of homogentisate to 4-maleylacetoacetate. Homogentisate 1,2-dioxygenase or HGD is involved in the catabolism of aromatic rings, more specifically in the breakdown of the amino acids tyrosine and phenylalanine. HGD appears in the metabolic pathway of tyrosine and phenylalanine degradation once the molecule homogentisate is produced. Homogentisate reacts with HGD to produce maleylacetoacetate, which then is further used in the metabolic pathway. HGD requires the use of Fe2+ and O2 in order to cleave the aromatic ring of homogentisate.
U.S. National Library of Medicine
Homogentisate 1,2-Dioxygenase
A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.
Numerology
Chaldean Numerology
The numerical value of homogentisate 1,2-dioxygenase in Chaldean Numerology is: 4
Pythagorean Numerology
The numerical value of homogentisate 1,2-dioxygenase in Pythagorean Numerology is: 9
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"homogentisate 1,2-dioxygenase." Definitions.net. STANDS4 LLC, 2024. Web. 29 Apr. 2024. <https://www.definitions.net/definition/homogentisate+1%2C2-dioxygenase>.
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