What does demethylating agent mean?
Definitions for demethylating agent
demethy·lat·ing agent
This dictionary definitions page includes all the possible meanings, example usage and translations of the word demethylating agent.
Wikipedia
Demethylating agent
Demethylating agents are chemical substances that can inhibit methylation, resulting in the expression of the previously hypermethylated silenced genes (see Methylation#Cancer for more detail). Cytidine analogs such as 5-azacytidine (azacitidine) and 5-azadeoxycytidine (decitabine) are the most commonly used demethylating agents. They work by inhibiting DNA methyltransferases. Both compounds have been approved in the treatment of myelodysplastic syndrome (MDS) by Food and Drug Administration (FDA) in United States. Azacitidine and decitabine are marketed as Vidaza and Dacogen respectively. Azacitidine is the first drug to be approved by FDA for treating MDS and has been given orphan drug status. Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. There are many other demethylating agents that can be used to inhibit the growth of other diseases.
Numerology
Chaldean Numerology
The numerical value of demethylating agent in Chaldean Numerology is: 9
Pythagorean Numerology
The numerical value of demethylating agent in Pythagorean Numerology is: 1
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"demethylating agent." Definitions.net. STANDS4 LLC, 2024. Web. 30 Apr. 2024. <https://www.definitions.net/definition/demethylating+agent>.
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