Definitions for dactinomycin

This page provides all possible meanings and translations of the word dactinomycin

Freebase

  1. Dactinomycin

    A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. (NCI04)

U.S. National Library of Medicine

  1. Dactinomycin

    A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)

Numerology

  1. Chaldean Numerology

    The numerical value of dactinomycin in Chaldean Numerology is: 3

  2. Pythagorean Numerology

    The numerical value of dactinomycin in Pythagorean Numerology is: 4

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