Definitions for dactinomycin

This page provides all possible meanings and translations of the word dactinomycin


  1. Dactinomycin

    A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. (NCI04)

U.S. National Library of Medicine

  1. Dactinomycin

    A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)


Find a translation for the dactinomycin definition in other languages:

Select another language:

Discuss these dactinomycin definitions with the community:

Word of the Day

Would you like us to send you a FREE new word definition delivered to your inbox daily?

Please enter your email address:     


Use the citation below to add this definition to your bibliography:


"dactinomycin." STANDS4 LLC, 2016. Web. 12 Feb. 2016. <>.

Are we missing a good definition for dactinomycin? Don't keep it to yourself...

Nearby & related entries:

Alternative searches for dactinomycin:

Thanks for your vote! We truly appreciate your support.