Definitions for coumestrol
coume·strol

WikipediaRate this definition:0.0 / 0 votes

1. Coumestrol

   Coumestrol is a natural organic compound in the class of phytochemicals known as coumestans. Coumestrol was first identified as a compound with estrogenic properties by E. M. Bickoff in ladino clover and alfalfa in 1957. It has garnered research interest because of its estrogenic activity and prevalence in some foods, including soybeans, brussels sprouts, spinach and a variety of legumes. The highest concentrations of coumestrol are found in clover, Kala Chana (a type of chick pea), and Alfalfa sprouts.Coumestrol is a phytoestrogen, mimicking the biological activity of estrogens. Phytoestrogens are able to pass through cell membranes due to their low molecular weight and stable structure, and they are able to interact with the enzymes and receptors of cells. Coumestrol binds to the ERα and ERβ with similar affinity to that of estradiol (94% and 185% of the relative binding affinity of estradiol at the ERα and ERβ, respectively), although the estrogenic activity of coumestrol at both receptors is much less than that of estradiol. In any case, coumestrol has estrogenic activity that is 30 to 100 times greater than that of isoflavones.The chemical shape of coumestrol orients its two hydroxy groups in the same position as the two hydroxy groups in estradiol, allowing it to inhibit the activity of aromatase and 3α-hydroxysteroid dehydrogenase. These enzymes are involved in the biosynthesis of steroid hormones, and inhibition of these enzymes results in the interference with hormone metabolism.

WikidataRate this definition:0.0 / 0 votes

1. Coumestrol

   Coumestrol is a natural organic compound in the class of phytochemicals known as coumestans. It has garnered research interest because of its estrogenic activity and its prevalence in some foods, such as soybeans. Coumestrol was first identified by E. M. Bickoff in alfalfa in 1957. It has since be found in a variety of legumes, soybeans, brussels sprouts, and spinach. Clover and soybeans have the highest concentrations. Coumestrol is a phytoestrogen, mimicking the biological activity of estrogens. Coumestrol has about the same binding affinity for the ER-β estrogen receptor as 17β-estradiol, but much less affinity for 17α-estradiol, although the estrogenic potency of coumestrol at both receptors is much less than that of 17β-estradiol. The chemical shape of coumestrol orients its two hydroxy groups in the same position as the two hydroxy groups in estradiol, allowing it to inhibit the activity of aromatase and hydroxysteroid dehydrogenase. These enzymes are involved in the biosynthesis of steroid hormones, and inhibition of these enzymes results in the modulation of hormone production.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Coumestrol

   A daidzein derivative occurring naturally in forage crops which has some estrogenic activity.

How to pronounce coumestrol?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

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   Indian

   Priya

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   Neerja

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   Zira

   US English

   Oliver

   British

   Wendy

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   Fred

   US English

   Tessa

   South African

How to say coumestrol in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of coumestrol in Chaldean Numerology is: 8

2. Pythagorean Numerology

   The numerical value of coumestrol in Pythagorean Numerology is: 6

References

1. ^ Wikipedia
   https://en.wikipedia.org/wiki/Coumestrol
2. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=coumestrol