Definitions for chymotrypsin
ˌkaɪ moʊˈtrɪp sɪnchy·mot·rypsin

WiktionaryRate this definition:0.0 / 0 votes

1. chymotrypsinnoun

   An endopeptidase enzyme that cleaves peptides at the carboxyl side of tyrosine, tryptophan, and phenylalanine amino acids.

WikipediaRate this definition:0.0 / 0 votes

1. Chymotrypsin

   Chymotrypsin (EC 3.4.21.1, chymotrypsins A and B, alpha-chymar ophth, avazyme, chymar, chymotest, enzeon, quimar, quimotrase, alpha-chymar, alpha-chymotrypsin A, alpha-chymotrypsin) is a digestive enzyme component of pancreatic juice acting in the duodenum, where it performs proteolysis, the breakdown of proteins and polypeptides. Chymotrypsin preferentially cleaves peptide amide bonds where the side chain of the amino acid N-terminal to the scissile amide bond (the P1 position) is a large hydrophobic amino acid (tyrosine, tryptophan, and phenylalanine). These amino acids contain an aromatic ring in their side chain that fits into a hydrophobic pocket (the S1 position) of the enzyme. It is activated in the presence of trypsin. The hydrophobic and shape complementarity between the peptide substrate P1 side chain and the enzyme S1 binding cavity accounts for the substrate specificity of this enzyme. Chymotrypsin also hydrolyzes other amide bonds in peptides at slower rates, particularly those containing leucine and methionine at the P1 position. Structurally, it is the archetypal structure for its superfamily, the PA clan of proteases.

WikidataRate this definition:0.0 / 0 votes

1. Chymotrypsin

   Chymotrypsin is a digestive enzyme component of pancreatic juice acting in the duodenum where it performs proteolysis, the breakdown of proteins and polypeptides. Chymotrypsin preferentially cleaves peptide amide bonds where the carboxyl side of the amide bond is a large hydrophobic amino acid. These amino acids contain an aromatic ring in their sidechain that fits into a 'hydrophobic pocket' of the enzyme. It is activated in the presence of trypsin. The hydrophobic and shape complementarity between the peptide substrate P1 sidechain and the enzyme S1 binding cavity accounts for the substrate specificity of this enzyme. Chymotrypsin also hydrolyzes other amide bonds in peptides at slower rates, particularly those containing leucine and methionine at the P1 position.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Chymotrypsin

   A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.

How to pronounce chymotrypsin?

1. Alex

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   Daniel

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   Libby

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Numerology

1. Chaldean Numerology

   The numerical value of chymotrypsin in Chaldean Numerology is: 8

2. Pythagorean Numerology

   The numerical value of chymotrypsin in Pythagorean Numerology is: 5

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Chymotrypsin
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Chymotrypsin
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=chymotrypsin