Definitions for choline kinase
choline kinase

WikipediaRate this definition:0.0 / 0 votes

1. Choline kinase

   Choline kinase (also known as CK, ChoK and choline phosphokinase) is an enzyme which catalyzes the first reaction in the choline pathway for phosphatidylcholine (PC) biosynthesis. This reaction involves the transfer of a phosphate group from adenosine triphosphate (ATP) to choline in order to form phosphocholine. ATP + choline ⇌ {\displaystyle \rightleftharpoons } ADP + O-phosphocholineThus, the two substrates of this enzyme are ATP and choline, whereas its two products are adenosine diphosphate (ADP) and O-phosphocholine. Choline kinase requires magnesium ions (+2) as a cofactor for this reaction. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The first detailed investigation of the enzyme was conducted by McCamen in 1962, where it was shown that the brain is the richest source of the enzyme in mammalian tissue. A related enzyme, ethanolamine kinase, tends to co-purify with choline kinase leading to a suggestion that the two activities are mediated by two distinct active sites on a single protein. The systematic name of this enzyme class is ATP:choline phosphotransferase. These enzymes participate in glycine, serine and threonine metabolism and glycerophospholipid metabolism. In mammalian cells, the enzyme exists as three isoforms: CKα-1, CKα-2 and CKβ. These isoforms are encoded by two separate genes, CHKA and CHKB and are only active in their homodimeric, heterodimeric and oligomeric forms.

WikidataRate this definition:0.0 / 0 votes

1. Choline kinase

   Choline Kinase is an enzyme which catalyzes the first reaction in the choline pathway for phosphatidylcholine biosynthesis.This reaction involves the transfer of a phosphate group from ATP to choline in order to form phosphocholine. Thus, the two substrates of this enzyme are ATP and choline, whereas its two products are ADP and O-phosphocholine.Choline Kinase requires magnesium ions as a cofactor for this reaction. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups with an alcohol group as acceptor. The first detailed investigation of the enzyme was conducted by McCamen in 1962, where it was shown that the brain is the richest source of the enzyme in mammalian tissue. A related enzyme, ethanolamine kinase tends to co-purify with choline kinase leading to a suggestion that the two activities are mediated by two distinct active sites on a single protein. The systematic name of this enzyme class is ATP:choline phosphotransferase. These enzymes participate in glycine, serine and threonine metabolism and glycerophospholipid metabolism. In mammalian cells, the enzyme exists as three isoforms,CKα-1,CKα-2 and CKβ. These isoforms are encoded by two separate genes, CHKA and CHKB and are only active in their homodimeric,heterodimeric and oligomeric forms.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Choline Kinase

   An enzyme that is active in the first step of choline phosphoglyceride (lecithin) biosynthesis by catalyzing the phosphorylation of choline to phosphorylcholine in the presence of ATP. Ethanolamine and its methyl and ethyl derivatives can also act as acceptors. EC 2.7.1.32.

How to pronounce choline kinase?

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Numerology

1. Chaldean Numerology

   The numerical value of choline kinase in Chaldean Numerology is: 1

2. Pythagorean Numerology

   The numerical value of choline kinase in Pythagorean Numerology is: 8

References

1. ^ Wikipedia
   https://en.wikipedia.org/wiki/Choline_Kinase
2. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=choline kinase