What does bromodeoxyuridine mean?
Definitions for bromodeoxyuridine
bro·mod·eoxyuri·dine
This dictionary definitions page includes all the possible meanings, example usage and translations of the word bromodeoxyuridine.
Wiktionary
bromodeoxyuridinenoun
A synthetic nucleoside which is an analogue of thymidine; it is commonly used in the detection of proliferating cells in living tissues, where it competes with uridine
Wikidata
Bromodeoxyuridine
Bromodeoxyuridine is a synthetic nucleoside that is an analogue of thymidine. BrdU is commonly used in the detection of proliferating cells in living tissues. 5-bromodeoxycytidine is deaminated to form BrdU. BrdU can be incorporated into the newly synthesized DNA of replicating cells, substituting for thymidine during DNA replication. Antibodies specific for BrdU can then be used to detect the incorporated chemical, thus indicating cells that were actively replicating their DNA. Binding of the antibody requires denaturation of the DNA, usually by exposing the cells to acid or heat. BrdU can be passed to daughter cells upon replication. BrdU has been demonstrated to be detectable over two years post-infusion. Because BrdU can replace thymidine during DNA replication, it can cause mutations, and its use is therefore potentially a health hazard. However, because it is neither radioactive nor myelotoxic at labeling concentrations, it is widely preferred for in vivo studies of cancer cell proliferation. However, at radiosensitizing concentrations, BrdU becomes myelosuppressive thus limiting its use for radiosensitizing.
U.S. National Library of Medicine
Bromodeoxyuridine
A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.
Numerology
Chaldean Numerology
The numerical value of bromodeoxyuridine in Chaldean Numerology is: 5
Pythagorean Numerology
The numerical value of bromodeoxyuridine in Pythagorean Numerology is: 9
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"bromodeoxyuridine." Definitions.net. STANDS4 LLC, 2024. Web. 26 Apr. 2024. <https://www.definitions.net/definition/bromodeoxyuridine>.
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