Definitions for argonaute
arg·onaute

WiktionaryRate this definition:0.0 / 0 votes

1. argonautenoun

   Any of a group of proteins responsible for the gene silencing phenomenon known as RNA interference

WikipediaRate this definition:0.0 / 0 votes

1. Argonaute

   The Argonaute protein family, first discovered for its evolutionarily conserved stem cell function, plays a central role in RNA silencing processes as essential components of the RNA-induced silencing complex (RISC). RISC is responsible for the gene silencing phenomenon known as RNA interference (RNAi). Argonaute proteins bind different classes of small non-coding RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). Small RNAs guide Argonaute proteins to their specific targets through sequence complementarity (base pairing), which then leads to mRNA cleavage, translation inhibition, and/or the initiation of mRNA decay.The name of this protein family is derived from a mutant phenotype resulting from mutation of AGO1 in Arabidopsis thaliana, which was likened by Bohmert et al. to the appearance of the pelagic octopus Argonauta argo.

WikidataRate this definition:0.0 / 0 votes

1. Argonaute

   Argonaute proteins are the catalytic components of the RNA-induced silencing complex, the protein complex responsible for the gene silencing phenomenon known as RNA interference. Argonaute proteins bind different classes of small non-coding RNAs, including microRNAs, small interfering RNAs and Piwi-interacting RNAs. Small RNAs guide Argonaute proteins to their specific targets through sequence complementarity, which typically leads to silencing of the target. Some of the Argonaute proteins have endonuclease activity directed against messenger RNA strands that display extensive complementarity to their bound small RNA, and this is known as Slicer activity. These proteins are also partially responsible for selection of the guide strand and destruction of the passenger strand of the siRNA substrate. The structural basis for binding of RNA to the Argonaute protein has been examined by X-ray crystallography of the binding domain of an RNA-bound argonaute protein. The phosphorylated 5' end of the RNA strand enters a conserved basic surface pocket and makes contacts through a divalent cation such as magnesium and by aromatic stacking between the 5' nucleotide in the siRNA and a conserved tyrosine residue. This site is thought to form a nucleation site for the binding of the siRNA to its mRNA target.

How to pronounce argonaute?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say argonaute in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of argonaute in Chaldean Numerology is: 7

2. Pythagorean Numerology

   The numerical value of argonaute in Pythagorean Numerology is: 3

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Argonaute
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Argonaute
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=argonaute