What does antifolate mean?
Definitions for antifolate
an·tifo·late
This dictionary definitions page includes all the possible meanings, example usage and translations of the word antifolate.
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Wiktionary
antifolatenoun
Any drug that inhibits the activity of folic acid; a folate antagonist
antifolateadjective
That inhibits the activity of folic acid
Wikipedia
Antifolate
Antifolates are a class of antimetabolite medications that antagonise (that is, block) the actions of folic acid (vitamin B9). Folic acid's primary function in the body is as a cofactor to various methyltransferases involved in serine, methionine, thymidine and purine biosynthesis. Consequently, antifolates inhibit cell division, DNA/RNA synthesis and repair and protein synthesis. Some such as proguanil, pyrimethamine and trimethoprim selectively inhibit folate's actions in microbial organisms such as bacteria, protozoa and fungi. The majority of antifolates work by inhibiting dihydrofolate reductase (DHFR).
Wikidata
Antifolate
Antifolates are drugs that impair the function of folic acids. Many are used in cancer chemotherapy, some are used as antibiotics or antiprotozoal agents. A well-known example is methotrexate. This is a folic acid analogue, and owing to structural similarity with it binds and inhibits the enzyme dihydrofolate reductase, and thus prevents the formation of tetrahydrofolate. Because tetrahydrofolate is essential for purine and pyrimidine synthesis, its deficiency can lead to inhibited production of DNA, RNA, and proteins. Since antifolates interfere with metabolism, they are categorized as antimetabolites. Other antifolates include trimethoprim, pyrimethamine, and pemetrexed. Many are primarily DHFR inhibitors, but raltitrexed is an inhibitor of thymidylate synthase, and pemetrexed inhibits both and a third enzyme.
Numerology
Chaldean Numerology
The numerical value of antifolate in Chaldean Numerology is: 3
Pythagorean Numerology
The numerical value of antifolate in Pythagorean Numerology is: 4
Translations for antifolate
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"antifolate." Definitions.net. STANDS4 LLC, 2024. Web. 9 May 2024. <https://www.definitions.net/definition/antifolate>.
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