Definitions for alendronate
This page provides all possible meanings and translations of the word alendronate
a tablet (trade name Fosamax) prescribed to prevent or treat osteoporosis in women after menopause
Any salt or ester of alendronic acid
The sodium salt of alendronic acid used to treat osteoporosis
U.S. National Library of Medicine
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
A second generation bisphosphonate and synthetic analog of pyrophosphate with anti-bone-resorption activity. Alendronic acid binds to and inhibits the activity of farnesyl pyrophosphate synthetase, an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids, donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which are important in the process of osteoclast turnover. As a result, bone resorption and turnover are reduced.
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