Definitions for Raloxifene
rəˈlɒk səˌfinralox·ifene

WiktionaryRate this definition:0.0 / 0 votes

1. raloxifenenoun

   A drug used in the treatment of osteoporosis

WikipediaRate this definition:0.0 / 0 votes

1. Raloxifene

   Raloxifene, sold under the brand name Evista among others, is a medication used to prevent and treat osteoporosis in postmenopausal women and those on glucocorticoids. For osteoporosis it is less preferred than bisphosphonates. It is also used to reduce the risk of breast cancer in those at high risk. It is taken by mouth.Common side effects include hot flashes, leg cramps, swelling, and joint pain. Severe side effects may include blood clots and stroke. Use during pregnancy may harm the baby. The medication may worsen menstrual symptoms. Raloxifene is a selective estrogen receptor modulator (SERM) and therefore a mixed agonist–antagonist of the estrogen receptor (ER). It has estrogenic effects in bone and antiestrogenic effects in the breasts and uterus.Raloxifene was approved for medical use in the United States in 1997. It is available as a generic medication. In 2020, it was the 292nd most commonly prescribed medication in the United States, with more than 1 million prescriptions.

WikidataRate this definition:0.0 / 0 votes

1. Raloxifene

   Raloxifene is an oral selective estrogen receptor modulator that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast. It is used in the prevention of osteoporosis in postmenopausal women. In 2006, the National Cancer Institute announced that raloxifene was as effective as tamoxifen in reducing the incidence of breast cancer in postmenopausal women at increased risk. A major adverse effect of tamoxifen is uterine cancer; raloxifene had fewer uterine cancers. Tamoxifen increased the risk of cataracts, but raloxifene did not. Both groups had more blood clots in veins and the lungs, but that side effect was more common with tamoxifen than raloxifene. On September 14, 2007, the U.S. Food and Drug Administration announced approval of raloxifene for reducing the risk of invasive breast cancer in postmenopausal women with osteoporosis and in postmenopausal women at high risk for invasive breast cancer. An editorial in Lancet Oncology criticized the way that information about the drug was released.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Raloxifene

   A second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.

How to pronounce Raloxifene?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say Raloxifene in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of Raloxifene in Chaldean Numerology is: 6

2. Pythagorean Numerology

   The numerical value of Raloxifene in Pythagorean Numerology is: 1

Examples of Raloxifene in a Sentence

1. Robert McLean:

   There is now a specific recommendation against using estrogen replacement therapy or raloxifene (Evista) for treatment of osteoporosis in women.

Popularity rank by frequency of use

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Raloxifene
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Raloxifene
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=Raloxifene