What does LANA mean?

Definitions for LANA
lana

This dictionary definitions page includes all the possible meanings, example usage and translations of the word LANA.


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Wiktionary

  1. Lananoun

    A female given name.

  2. Etymology: Short form of Alana, or from Лана, diminutive of several names icluding Светлана.

Wikipedia

  1. LANA

    The latency-associated nuclear antigen (LANA-1) or latent nuclear antigen (LNA, LNA-1) is a Kaposi's sarcoma-associated herpesvirus (KSHV) latent protein initially found by Moore and colleagues as a speckled nuclear antigen present in primary effusion lymphoma cells that reacts with antibodies from patients with KS. It is the most immunodominant KSHV protein identified by Western-blotting as 222–234 kDa double bands migrate slower than the predicted molecular weight. LANA has been suspected of playing a crucial role in modulating viral and cellular gene expression. It is commonly used as an antigen in blood tests to detect antibodies in persons that have been exposed to KSHV.KSHV or Human herpesvirus 8 (HHV-8) has been identified as the etiological agent of Kaposi’s sarcoma (KS) and certain AIDS-associated lymphomas. As KSHV establishes latent infection in tumorous foci, it invariably expresses high levels of the viral LANA protein, which is necessary and sufficient to maintain the KSHV episome. Encoded by ORF73, LANA-1 is one of few HHV-8 encoded proteins that is highly expressed in all latently infected tumour cells; specifically, it is a phosphoprotein with an acidic internal repeat domain flanked by a carboxy-terminal domain and an amino-terminal domain. LANA-1 acts as a transcriptional regulator, and it has been implicated directly in oncogenesis because of its ability to bind to the tumour-suppressing protein p53 and to the retinoblastoma protein pRb. This leads to the inactivation of p53-dependent promoters and induction of E2F-dependent genes.Studies have also shown that LANA-1 can transactivate the promoter of the reverse transcriptase subunit of the human telomerase holoenzyme, thus overextending a critical step in cellular transformation. Paradoxically, LANA-1 has been shown to be involved in transcriptional repression and can, moreover, interact with the mSin3/HDAC1 co-repressor complex.It has been also shown to interact with and inhibit the ATF4/CREB2 transcription factor that interacts with the basic transcription machinery and to bind with two human chromosome-associated cellular proteins, MeCP2 and DEK.LANA-1 is associated with cellular chromatin and stays on the chromosomes during cell division. It maintains the viral genomes during cell division by tethering the viral episomes to the chromosomes. It binds directly to replication origin recognition complexes (ORCs) that are primarily associated with the terminal repeat (TR) region of the HHV-8 genome.

Wikidata

  1. Lana

    Lana is a comune in South Tyrol in northern Italy. It is situated between Bolzano and Merano. The population rose to 11,206 in 2010. It is one of the three municipalities of South Tyrol whose name remained unchanged by the Italian fascist renaming programme which aimed at replacing mostly German place names with Italianized versions, the other two being Gais and Plaus.

Chambers 20th Century Dictionary

  1. Lana

    lä′na, n. the tough, close-grained wood of a Guiana tree.

Suggested Resources

  1. LANA

    What does LANA stand for? -- Explore the various meanings for the LANA acronym on the Abbreviations.com website.

Entomology

  1. Lana

    wool: the long hair on the abdomen of some Lepidoptera.

Surnames Frequency by Census Records

  1. LANA

    According to the U.S. Census Bureau, Lana is ranked #28380 in terms of the most common surnames in America.

    The Lana surname appeared 841 times in the 2010 census and if you were to sample 100,000 people in the United States, approximately 0 would have the surname Lana.

    67.4% or 567 total occurrences were White.
    18.4% or 155 total occurrences were of Hispanic origin.
    6.5% or 55 total occurrences were Asian.
    5.9% or 50 total occurrences were Black.

Anagrams for LANA »

  1. Alan

  2. alan

  3. Anal

  4. anal

How to pronounce LANA?

How to say LANA in sign language?

Numerology

  1. Chaldean Numerology

    The numerical value of LANA in Chaldean Numerology is: 1

  2. Pythagorean Numerology

    The numerical value of LANA in Pythagorean Numerology is: 1

Examples of LANA in a Sentence

  1. Del Rey:

    Everyone knows that I’m here, lana knows I’m here. The queen of England knows I’m here. Vladimir knows I’m here. They all know I’m here.

Popularity rank by frequency of use

LANA#10000#23545#100000

Translations for LANA

From our Multilingual Translation Dictionary

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"LANA." Definitions.net. STANDS4 LLC, 2024. Web. 19 Mar. 2024. <https://www.definitions.net/definition/LANA>.

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