Definitions for L1
This page provides all possible meanings and translations of the word L1
first Lagrange point, located further in twoards the primary of a system where a smaller object orbits a larger one, in front of the smaller object, inline with a line drawn through the centres of the larger and smaller objects
mother tongue (someone's native language)
Origin: From language 1, meaning "first language."
L1, also known as L1CAM, is a transmembrane protein; it is a neuronal cell adhesion molecule, member of the L1 protein family, of 200-220 kDa, and involved in axon guidance and cell migration with a strong implication in treatment-resistant cancers. L1CAM has also been designated CD171. The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin superfamily of proteins. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats, is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration, and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH. Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
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