Definitions for Isostere
isostere

WiktionaryRate this definition:3.0 / 2 votes

1. isosterenoun

   Either of a group of molecules or ions that have the same number of atoms and the same number of valence electrons

WikipediaRate this definition:0.0 / 0 votes

1. Isostere

   Classical Isosteres are molecules or ions with similar shape and often electronic properties. Many definitions are available. but the term is usually employed in the context of bioactivity and drug development. Such biologically-active compounds containing an isostere is called a bioisostere. This is frequently used in drug design: the bioisostere will still be recognized and accepted by the body, but its functions there will be altered as compared to the parent molecule.

WikidataRate this definition:5.0 / 1 vote

1. Isostere

   Classical Isosteres are molecules or ions with the same number of atoms and/or the same number of valence electrons. The definition was later revised to include compounds with similarly reactive electron shells. For example, Hydrogen ion and Fluoride are classical isosteres because they both have relatively small nuclei and their outer valence shells are full when ionized. Non-Classical Isosteres do not obey the above classifications, but they still produce similar biological effects in vivo. Non-classical isosteres may be made up of similar atoms, but their structures do not follow an easily-definable set of rules. Some examples of isosteres include: ⁕Sodium and hydrogen cations ⁕Carbon dioxide and nitrous oxide ⁕Silicon and carbon ⁕methyl, amide, and hydroxyl groups The isostere concept was formulated by Irving Langmuir in 1919, and later modified by Grimm. Friedrich Erlenmeyer extended the concept to biological systems in 1932. Classical isosteres are defined as being atoms, ions and molecules that had identical outer shells of electrons, This definition has now been broadened to include groups that produce compounds that can sometimes have similar biological activities. Some evidence for the validity of this notion was the observation that some pairs, such as benzene and thiophene, thiophene and furan, and even benzene and pyridine, exhibited similarities in many physical and chemical properties.

Anagrams for Isostere »

1. erotesis

2. erotises

How to pronounce Isostere?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say Isostere in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of Isostere in Chaldean Numerology is: 3

2. Pythagorean Numerology

   The numerical value of Isostere in Pythagorean Numerology is: 2

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Isostere
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Isostere
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=Isostere