What does 12-o-tetradecanoylphorbol-13-acetate mean?
Definitions for 12-o-tetradecanoylphorbol-13-acetate
12-o-tetrade·canoylphor·bol-13-acetate
This dictionary definitions page includes all the possible meanings, example usage and translations of the word 12-o-tetradecanoylphorbol-13-acetate.
Wikipedia
12-O-Tetradecanoylphorbol-13-acetate
12-O-Tetradecanoylphorbol-13-acetate (TPA), also commonly known as tetradecanoylphorbol acetate, tetradecanoyl phorbol acetate, and phorbol 12-myristate 13-acetate (PMA) is a diester of phorbol. It is a potent tumor promoter often employed in biomedical research to activate the signal transduction enzyme protein kinase C (PKC). The effects of TPA on PKC result from its similarity to one of the natural activators of classic PKC isoforms, diacylglycerol. TPA is a small molecule drug. In ROS biology, superoxide was identified as the major reactive oxygen species induced by TPA/PMA but not by ionomycin in mouse macrophages. Thus, TPA/PMA has been routinely used as an inducer for endogenous superoxide production.TPA is also being studied as a drug in the treatment of hematologic cancerTPA has a specific use in cancer diagnostics as a B-cell specific mitogen in cytogenetic testing. To view the chromosomes, a cytogenetic test requires dividing cells. TPA is used to stimulate division of B-cells during cytogenetic diagnosis of B-cell cancers such as chronic lymphocytic leukemia.TPA is also commonly used together with ionomycin to stimulate T-cell activation, proliferation, and cytokine production, and is used in protocols for intracellular staining of these cytokines.TPA induces KSHV reactivation in PEL cell cultures via stimulation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway. The pathway involves the activation of the early-immediate viral protein RTA that contributes to the activation of the lytic cycle.TPA was first found in the croton plant, a shrub found in Southeast Asia, exposure to which provokes a poison ivy-like rash. It underwent a phase 1 clinical trial.
Numerology
Chaldean Numerology
The numerical value of 12-o-tetradecanoylphorbol-13-acetate in Chaldean Numerology is: 1
Pythagorean Numerology
The numerical value of 12-o-tetradecanoylphorbol-13-acetate in Pythagorean Numerology is: 2
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"12-o-tetradecanoylphorbol-13-acetate." Definitions.net. STANDS4 LLC, 2024. Web. 27 Apr. 2024. <https://www.definitions.net/definition/12-o-tetradecanoylphorbol-13-acetate>.
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