What does tolcapone mean?

Here's a list of possible definitions for the term tolcapone:


  1. Tolcapone

    Tolcapone (brand name Tasmar) is a drug used to treat Parkinson's disease (PD). It is a selective, potent and reversible nitrocatechol-type inhibitor of the enzyme catechol-O-methyltransferase (COMT). It has demonstrated significant liver toxicity, which has led to suspension of marketing authorisations in a number of countries. In comparison with entacapone, another nitrocatechol COMT inhibitor, tolcapone has a longer half life (2.9 hours vs. 0.8 hours) and can better penetrate the blood–brain barrier, acting both in the central nervous system and in the periphery. However, entacapone is less toxic for the liver.


  1. Chaldean Numerology

    The numerical value of tolcapone in Chaldean Numerology is: 7

  2. Pythagorean Numerology

    The numerical value of tolcapone in Pythagorean Numerology is: 2

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