What does wolman disease mean?

Definitions for wolman disease

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  1. Wolman disease

    Wolman Disease . This enzyme is necessary to break down certain lipids inside the cells. Deficiency of the LAL/LIPA enzyme causes a build-up of fat in the liver, gut and other parts of the body. ⁕Wolman disease belongs to a group of diseases known as Lysosomal Storage Disorders (LSDs). ⁕Lysosomes function as recycling centers within cells breaking down a number of unwanted materials into substances that the cell can reuse. ⁕Enzymes are highly specialized proteins within lysosomes that break down or digest particular nutrients, such as certain fats and carbohydrates. ⁕When these enzymes are defective or missing altogether because of genetic mutations, LSDs develop as a result of abnormal build-up of material in the body's cells. ⁕Wolman disease is the early onset form of LAL Deficiency. ⁕This form of the disease typically develops during the first few weeks or month of life. ⁕Late onset form which is known as Cholesteryl ester storage disease (CESD) typically presents later in childhood or even adulthood.

U.S. National Library of Medicine

  1. Wolman Disease

    The severe infantile form of inherited lysosomal lipid storage diseases due to deficiency of acid lipase (STEROL ESTERASE). It is characterized by the accumulation of neutral lipids, particularly CHOLESTEROL ESTERS in leukocytes, fibroblasts, and hepatocytes. It is also known as Wolman's xanthomatosis and is an allelic variant of CHOLESTEROL ESTER STORAGE DISEASE.


  1. Chaldean Numerology

    The numerical value of wolman disease in Chaldean Numerology is: 3

  2. Pythagorean Numerology

    The numerical value of wolman disease in Pythagorean Numerology is: 5

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  1. wolman disease


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