Definitions for warfarin
ˈwɔr fə rɪnwar·farin

Princeton's WordNetRate this definition:0.0 / 0 votes

1. warfarin, Coumadinnoun

   an anticoagulant (trade name Coumadin) use to prevent and treat a thrombus or embolus

WiktionaryRate this definition:0.0 / 0 votes

1. warfarinnoun

   An anticoagulant medication that is used for the prophylaxis of thrombosis and embolism in many disorders.

WikipediaRate this definition:0.0 / 0 votes

1. Warfarin

   Warfarin, sold under the brand name Coumadin among others, is a medication that is used as an anticoagulant (blood thinner). It is commonly used to prevent blood clots such as deep vein thrombosis and pulmonary embolism, and to prevent stroke in people who have atrial fibrillation, valvular heart disease, or artificial heart valves. Less commonly, it is used following ST-segment elevation myocardial infarction and orthopedic surgery. It is generally taken by mouth, but may also be used intravenously.The common side effect is bleeding. Less common side effects may include areas of tissue damage and purple toes syndrome. Use is not recommended during pregnancy. The effects of warfarin typically should be monitored by checking prothrombin time (INR) every one to four weeks. Many other medications and dietary factors can interact with warfarin, either increasing or decreasing its effectiveness. The effects of warfarin may be reversed with phytomenadione (vitamin K1), fresh frozen plasma, or prothrombin complex concentrate.Warfarin decreases blood clotting by blocking an enzyme called vitamin K epoxide reductase that reactivates vitamin K1. Without sufficient active vitamin K1, clotting factors II, VII, IX, and X have decreased clotting ability. The anticlotting protein C and protein S are also inhibited, but to a lesser degree. A few days are required for full effect to occur, and these effects can last for up to five days. Additionally, because the mechanism involves enzymes such as VKORC1, patients on warfarin with polymorphisms of the enzymes may require adjustments in therapy to account if the genetic variant that they have is more readily inhibited by warfarin, thus requiring lower doses.Warfarin first came into large-scale commercial use in 1948 as a rat poison. Warfarin was formally approved for human use by the U.S. Food and Drug Administration to treat blood clots in 1954. In 1955, warfarin's reputation as a safe and acceptable treatment was bolstered when President Dwight D. Eisenhower received warfarin following a massive and highly publicized heart attack. Eisenhower's illness kickstarted a transformation in medicine where coronary artery disease, arterial plaques, and ischemic strokes were treated and prevented by using anticoagulants such as warfarin. It is on the World Health Organization's List of Essential Medicines. Warfarin is available as a generic medication. In 2020, it was the 58th most commonly prescribed medication in the United States, with more than 11 million prescriptions.

ChatGPTRate this definition:0.0 / 0 votes

1. warfarin

   Warfarin is a type of medication known as an anticoagulant, or blood thinner, which is prescribed to prevent and treat blood clots. The drug works by reducing the formation of blood clots in your veins, arteries, lungs, and heart, thus preventing heart attacks, strokes, and other heart-related problems. The name is derived from its discovery at the Wisconsin Alumni Research Foundation (WARF), plus the ending -arin indicating its link with coumarin, the chemical class to which it belongs.

WikidataRate this definition:0.0 / 0 votes

1. Warfarin

   Warfarin is an anticoagulant normally used in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migration elsewhere in the body respectively. It was initially introduced in 1948 as a pesticide against rats and mice and is still used for this purpose, although more potent poisons such as brodifacoum have since been developed. In the early 1950s warfarin was found to be effective and relatively safe for preventing thrombosis and embolism in many disorders. It was approved for use as a medication in 1954 and has remained popular ever since; warfarin is the most widely prescribed oral anticoagulant drug in North America. Despite its effectiveness, treatment with warfarin has several shortcomings. Many commonly used medications interact with warfarin, as do some foods and its activity has to be monitored by blood testing for the international normalized ratio to ensure an adequate yet safe dose is taken. A high INR predisposes to a high risk of bleeding, while an INR below the therapeutic target indicates that the dose of warfarin is insufficient to protect against thromboembolic events.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Warfarin

   An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.

Matched Categories

1. • Anticoagulant

How to pronounce warfarin?

1. Alex

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   David

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   Daniel

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   Libby

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How to say warfarin in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of warfarin in Chaldean Numerology is: 8

2. Pythagorean Numerology

   The numerical value of warfarin in Pythagorean Numerology is: 9

Popularity rank by frequency of use

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=warfarin
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Warfarin
3. ^ Wikipedia
   https://en.wikipedia.org/wiki/Warfarin
4. ^ ChatGPT
   https://chat.openai.com
5. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=warfarin