Definitions for waldenström's macroglobulinemia
walden·ström's macroglob·u·line·mi·a

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1. waldenström's macroglobulinemia

   Waldenström macroglobulinemia ( VAL-dən-strom MAK-roh-GLOB-yə-lə-NEE-mee-ə, US also VAHL-dən-strem -⁠) is a type of cancer affecting two types of B cells: lymphoplasmacytoid cells and plasma cells. Both cell types are white blood cells. It is characterized by having high levels of a circulating antibody, immunoglobulin M (IgM), which is made and secreted by the cells involved in the disease. Waldenström macroglobulinemia is an "indolent lymphoma" (i.e., one that tends to grow and spread slowly) and a type of lymphoproliferative disease which shares clinical characteristics with the indolent non-Hodgkin lymphomas. It is commonly classified as a form of plasma cell dyscrasia, similar to other plasma cell dyscrasias that, for example, lead to multiple myeloma. Waldenström macroglobulinemia is commonly preceded by two clinically asymptomatic but progressively more pre-malignant phases, IgM monoclonal gammopathy of undetermined significance and smoldering Waldenström macroglobulinemia. The Waldenström macroglobulinemia spectrum of dysplasias differs from other spectrums of plasma cell dyscrasias in that it involves not only aberrant plasma cells but also aberrant lymphoplasmacytoid cells and that it involves IgM while other plasma dyscrasias involve other antibody isoforms.Waldenström macroglobulinemia is a rare disease, with only about 1,500 cases per year in the United States. It occurs more frequently in older adults. While the disease is incurable, it is treatable. Because of its indolent nature, many patients are able to lead active lives, and when treatment is required, may experience years of symptom-free remission.

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1. Waldenström's macroglobulinemia

   Waldenström's macroglobulinemia is cancer affecting B cells, a type of white blood cell. The main attributing antibody is immunoglobulin M. WM is an "indolent lymphoma,". It is a type of lymphoproliferative disease, which shares clinical characteristics with the indolent non-Hodgkin lymphomas. The disease, named after the Swedish oncologist Jan G. Waldenström, was first identified in 1944. As with other lymphomas, the disease is characterized by an uncontrolled increase of B-cells, i.e., white blood cells formed in the bone marrow and lymph nodes. The proliferation of B-cells interferes with the production of red blood cells, resulting in anemia. A unique characteristic of the disease is that the B-cells produce excess amounts of immunoglobulin protein, thickening the blood, and requiring additional treatment. WM is a rare disease, with only about 1,500 cases per year in the U.S. While the disease is incurable, it is treatable. Because of its indolent nature, many patients are able to lead active lives, and, when treatment is required, may experience years of symptom-free remission.

How to pronounce waldenström's macroglobulinemia?

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Numerology

1. Chaldean Numerology

   The numerical value of waldenström's macroglobulinemia in Chaldean Numerology is: 8

2. Pythagorean Numerology

   The numerical value of waldenström's macroglobulinemia in Pythagorean Numerology is: 3

References

1. ^ Wikipedia
   https://en.wikipedia.org/wiki/Waldenstrom'S_Macroglobulinemia
2. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=waldenström's macroglobulinemia