What does transglutaminases mean?
Definitions for transglutaminases
trans·g·lu·tam·i·nas·es
This dictionary definitions page includes all the possible meanings, example usage and translations of the word transglutaminases.
Wikipedia
transglutaminases
Transglutaminases are enzymes that in nature primarily catalyze the formation of an isopeptide bond between γ-carboxamide groups ( -(C=O)NH2 ) of glutamine residue side chains and the ε-amino groups ( -NH2 ) of lysine residue side chains with subsequent release of ammonia ( NH3 ). Lysine and glutamine residues must be bound to a peptide or a protein so that this cross-linking (between separate molecules) or intramolecular (within the same molecule) reaction can happen. Bonds formed by transglutaminase exhibit high resistance to proteolytic degradation (proteolysis). The reaction is Gln-(C=O)NH2 + NH2-Lys → Gln-(C=O)NH-Lys + NH3Transglutaminases can also join a primary amine ( RNH2 ) to the side chain carboxyamide group of a protein/peptide bound glutamine residue thus forming an isopeptide bond Gln-(C=O)NH2 + RNH2 → Gln-(C=O)NHR + NH3These enzymes can also deamidate glutamine residues to glutamic acid residues in the presence of water Gln-(C=O)NH2 + H2O → Gln-COOH + NH3Transglutaminase isolated from Streptomyces mobaraensis -bacteria for example, is a calcium-independent enzyme. Mammalian transglutaminases among other transglutaminases require Ca2+ ions as a cofactor.Transglutaminases were first described in 1959. The exact biochemical activity of transglutaminases was discovered in blood coagulation protein factor XIII in 1968.
U.S. National Library of Medicine
Transglutaminases
Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.
Numerology
Chaldean Numerology
The numerical value of transglutaminases in Chaldean Numerology is: 9
Pythagorean Numerology
The numerical value of transglutaminases in Pythagorean Numerology is: 6
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"transglutaminases." Definitions.net. STANDS4 LLC, 2024. Web. 24 Apr. 2024. <https://www.definitions.net/definition/transglutaminases>.
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