What does thyroxine-binding globulin mean?

Definitions for thyroxine-binding globulin
thy·rox·ine-bind·ing glob·u·lin

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  1. Thyroxine-binding globulin

    Thyroxine-binding globulin binds thyroid hormone in circulation. It is one of three proteins responsible for carrying the thyroid hormones thyroxine and 3,5,3’-triiodothyronine in the bloodstream. Of these three proteins, TBG has the highest affinity for T4 and T3, but is present in the lowest concentration. Despite its low concentration, TBG carries the majority of T4 in the blood. Due to the very low concentration of T4 & T3 in the blood, TBG is rarely more than 25% saturated with its ligand. Unlike transthyretin and albumin, TBG has a single binding site for T4/T3. TBG is synthesized primarily in the liver as a 54 kDa protein. In terms of genomics, TBG is a serpin; however, it has no inhibitory function like many other members of this class of proteins.

U.S. National Library of Medicine

  1. Thyroxine-Binding Globulin

    A thyroid hormone transport protein found in serum. It binds about 75% of circulating THYROXINE and 70% of circulating TRIIODOTHYRONINE.

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  1. Chaldean Numerology

    The numerical value of thyroxine-binding globulin in Chaldean Numerology is: 5

  2. Pythagorean Numerology

    The numerical value of thyroxine-binding globulin in Pythagorean Numerology is: 1

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  1. thyroxine-binding globulin


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