What does thymopoiesis mean?

Definitions for thymopoiesis
thy·mopoiesis

This dictionary definitions page includes all the possible meanings, example usage and translations of the word thymopoiesis.


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Wiktionary

  1. thymopoiesisnoun

    The production of thymocytes, which later become T cells

Wikipedia

  1. thymopoiesis

    A Thymocyte is an immune cell present in the thymus, before it undergoes transformation into a T cell. Thymocytes are produced as stem cells in the bone marrow and reach the thymus via the blood. Thymopoiesis describes the process which turns thymocytes into mature T cells according to either negative or positive selection. This selection process is vitally important in shaping the population of thymocytes into a peripheral pool of T cells that are able to respond to foreign pathogens but remain tolerant towards the body's own antigens. Positive selection selects cells which are able to bind MHC class I or II molecules with at least a weak affinity. This eliminates (by a process called "death by neglect") those T cells which would be non-functional due to an inability to bind MHC. Negative selection destroys thymocytes with a high affinity for self peptides or MHC. This eliminates cells which would direct immune responses towards self-proteins in the periphery. Negative selection is not 100% effective, and some autoreactive T cells escape and are released into the circulation. Additional mechanisms of peripheral tolerance exist to silence these cells, but if these fail, autoimmunity may arise.

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Numerology

  1. Chaldean Numerology

    The numerical value of thymopoiesis in Chaldean Numerology is: 4

  2. Pythagorean Numerology

    The numerical value of thymopoiesis in Pythagorean Numerology is: 2

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"thymopoiesis." Definitions.net. STANDS4 LLC, 2024. Web. 19 Apr. 2024. <https://www.definitions.net/definition/thymopoiesis>.

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