Definitions for thapsigargin
thap·si·gar·gin

WiktionaryRate this definition:0.0 / 0 votes

1. thapsigarginnoun

   A sesquiterpene lactone that is an inhibitor of a certain class of enzymes

WikipediaRate this definition:0.0 / 0 votes

1. Thapsigargin

   Thapsigargin is a non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). Structurally, thapsigargin is classified as a guaianolide, and is extracted from a plant, Thapsia garganica. It is a tumor promoter in mammalian cells.Thapsigargin raises cytosolic (intracellular) calcium concentration by blocking the ability of the cell to pump calcium into the sarcoplasmic and endoplasmic reticula. Store-depletion can secondarily activate plasma membrane calcium channels, allowing an influx of calcium into the cytosol. Depletion of ER calcium stores leads to ER stress and activation of the unfolded protein response. Non-resolved ER stress can cumulatively lead to cell death. Prolonged store depletion can protect against ferroptosis via remodeling of ER-synthesized phospholipids.Thapsigargin treatment and the resulting ER calcium depletion inhibits autophagy independent of the UPR.Thapsigargin is useful in experimentation examining the impacts of increasing cytosolic calcium concentrations and ER calcium depletion. A study from the University of Nottingham showed promising results for its use against Covid-19 and other coronavirus.

WikidataRate this definition:0.0 / 0 votes

1. Thapsigargin

   Thapsigargin is non-competitive inhibitor of a class of enzymes known by the acronym SERCA, which stands for sarco / endoplasmic reticulum Ca2+ ATPase. Structurally, thapsigargin is classified as a sesquiterpene lactone, and is extracted from a plant, Thapsia garganica. It is a tumor promoter in mammalian cells. The anti-malarial drug artemisinin is also a sesquiterpene lactone, leading to a proposal that this class of drugs works by inhibiting the SERCA of malaria parasites such as Plasmodium falciparum; this hypothesis awaits confirmation. Thapsigargin raises cytosolic calcium concentration by blocking the ability of the cell to pump calcium into the sarcoplasmic and endoplasmic reticula which causes these stores to become depleted. Store-depletion can secondarily activate plasma membrane calcium channels, allowing an influx of calcium into the cytosol. Thapsigargin specifically inhibits the fusion of autophagosomes with lysosomes; the last step in the autophagic process. The inhibition of the autophagic process in turn induces stress on the endoplasmic reticulum which ultimately leads to cellular death. Thapsigargin is useful in experimentation examining the impacts of increasing cytosolic calcium concentrations.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Thapsigargin

   A sesquiterpene lactone found in roots of THAPSIA. It inhibits CA(2+)-TRANSPORTING ATPASE mediated uptake of CALCIUM into SARCOPLASMIC RETICULUM.

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Numerology

1. Chaldean Numerology

   The numerical value of thapsigargin in Chaldean Numerology is: 1

2. Pythagorean Numerology

   The numerical value of thapsigargin in Pythagorean Numerology is: 3

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Thapsigargin
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Thapsigargin
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=thapsigargin