Definitions for terfenadine
ter·fe·na·dine

WiktionaryRate this definition:0.0 / 0 votes

1. terfenadinenoun

   An antihistamine drug formerly used to treat allergic conditions, superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia.

WikipediaRate this definition:0.0 / 0 votes

1. Terfenadine

   Terfenadine is an antihistamine formerly used for the treatment of allergic conditions. It was brought to market by Hoechst Marion Roussel (now Sanofi-Aventis) and was marketed under various brand names, including Seldane in the United States, Triludan in the United Kingdom, and Teldane in Australia. It was superseded by fexofenadine in the 1990s due to the risk of a particular type of disruption of the electrical rhythms of the heart (specifically cardiac arrhythmia caused by QT interval prolongation) and has been withdrawn from markets worldwide.: 53 

WikidataRate this definition:0.0 / 0 votes

1. Terfenadine

   Terfenadine was an antihistamine formerly used for the treatment of allergic conditions. It was brought to market by Hoechst Marion Roussel and marketed under various brand names, including Seldane in the United States, Triludan in the United Kingdom, and Teldane in Australia. According to its manufacturer, terfenadine had been used by over 100 million patients worldwide as of 1990. It was superseded by fexofenadine in the 1990s due to the risk of a particular type of disruption of the electrical rhythms of the heart. Terfenadine is a prodrug, generally completely metabolized to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform. Due to its near complete metabolism by the liver immediately after leaving the gut, terfenadine normally is not measurable in the plasma. Terfenadine itself, however, is cardiotoxic at higher doses, while its major active metabolite is not. The reason for the differences in cardiotoxicity between Terfenadine and fexofenadine is not fully understood. Toxicity is possible after years of continued use with no previous problems as a result of an interaction with other medications such as erythromycin, or foods such as grapefruit. The addition of, or dosage change in, these CYP3A4 inhibitors makes it harder for the body to metabolize and remove terfenadine. In larger plasma concentrations, it may lead to toxic effects on the heart's rhythm.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Terfenadine

   A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.

How to pronounce terfenadine?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say terfenadine in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of terfenadine in Chaldean Numerology is: 9

2. Pythagorean Numerology

   The numerical value of terfenadine in Pythagorean Numerology is: 2

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Terfenadine
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Terfenadine
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=terfenadine