Definitions for sonic hedgehog
son·ic hedge·hog

WiktionaryRate this definition:5.0 / 1 vote

1. sonic hedgehognoun

   A morphogenic protein that controls cell division of adult stem cells and has been implicated in development of some cancers.

2. Etymology: Named after the video game character.

WikipediaRate this definition:0.0 / 0 votes

1. sonic hedgehog

   Sonic hedgehog protein (SHH) is encoded for by the SHH gene. The protein is named after the character Sonic the Hedgehog. This signaling molecule is key in regulating embryonic morphogenesis in all animals. SHH controls organogenesis and the organization of the central nervous system, limbs, digits and many other parts of the body. Sonic hedgehog is a morphogen that patterns the developing embryo using a concentration gradient characterized by the French flag model. This model has a non-uniform distribution of SHH molecules which governs different cell fates according to concentration. Mutations in this gene can cause holoprosencephaly, a failure of splitting in the cerebral hemispheres, as demonstrated in an experiment using SHH knock-out mice in which the forebrain midline failed to develop and instead only a single fused telencephalic vesicle resulted.Sonic hedgehog still plays a role in differentiation, proliferation, and maintenance of adult tissues. Abnormal activation of SHH signaling in adult tissues has been implicated in various types of cancers including breast, skin, brain, liver, gallbladder and many more.

WikidataRate this definition:5.0 / 1 vote

1. Sonic hedgehog

   Sonic hedgehog is a protein that in humans is encoded by the SHH gene. Sonic hedgehog is one of three proteins in the mammalian signaling pathway family called hedgehog, the others being desert hedgehog and Indian hedgehog. SHH is the best studied ligand of the hedgehog signaling pathway. It plays a key role in regulating vertebrate organogenesis, such as in the growth of digits on limbs and organization of the brain. Sonic hedgehog is the best established example of a morphogen as defined by Lewis Wolpert's French flag model—a molecule that diffuses to form a concentration gradient and has different effects on the cells of the developing embryo depending on its concentration. SHH remains important in the adult. It controls cell division of adult stem cells and has been implicated in development of some cancers.

How to pronounce sonic hedgehog?

1. Alex

   US English

   David

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   Mark

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   Daniel

   British

   Libby

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   Mia

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   Karen

   Australian

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   Australian

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   Neerja

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How to say sonic hedgehog in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of sonic hedgehog in Chaldean Numerology is: 2

2. Pythagorean Numerology

   The numerical value of sonic hedgehog in Pythagorean Numerology is: 2

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Sonic_Hedgehog
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Sonic_Hedgehog
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=sonic hedgehog