Definitions for sildenafil
silde·nafil

Princeton's WordNetRate this definition:4.5 / 2 votes

1. sildenafil, sildenafil citrate, Viagranoun

   virility drug (trade name Viagra) used to treat erectile dysfunction in men

WiktionaryRate this definition:0.0 / 0 votes

1. sildenafilnoun

   A drug, whose citrate is marketed as Viagra; a treatment for erectile dysfunction.

WikipediaRate this definition:0.0 / 0 votes

1. Sildenafil

   Sildenafil, sold under the brand name Viagra, among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. It is unclear if it is effective for treating sexual dysfunction in women. It is taken by mouth or by injection into a vein. Onset is typically within twenty minutes and lasts for about two hours.Common side effects include headaches, heartburn, and flushed skin. Caution is advised in those with cardiovascular disease. Rare but serious side effects include a prolonged erection (priapism) that can lead to damage to the penis, vision problems, and hearing loss. Sildenafil should not be taken by people on nitrates such as nitroglycerin (glycerin trinitrate), as this may result in a serious drop in blood pressure. Sildenafil should not be taken within four hours of taking an alpha blocker. Sildenafil acts by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. It requires sexual arousal to work. It also results in dilation of the blood vessels in the lungs.Pfizer originally discovered the medication in 1989 while looking for a treatment for heart-related chest pain. It was approved for medical use in the United States and in the European Union in 1998. In 2020, it was the 183rd most commonly prescribed medication in the United States, with more than 2 million prescriptions. It is available as a generic medication. In the United Kingdom, it is available over the counter. Most of the Active Pharmaceutical Ingredient (API) in Sildenafil, Sildenafil citrate, is produced in Pfizer's Ringaskiddy complex, County Cork, which is Pfizer's largest production facility outside of the United States.

ChatGPTRate this definition:0.0 / 0 votes

1. sildenafil

   Sildenafil is a medication primarily used to treat erectile dysfunction (impotence) and pulmonary arterial hypertension. It is a phosphodiesterase type 5 (PDE5) inhibitor that relaxes muscles and increases blood flow to specific areas of the body, particularly the penis, facilitating a healthy erection in men.

WikidataRate this definition:0.0 / 0 votes

1. Sildenafil

   Sildenafil citrate, sold as Viagra, Revatio and under various other trade names, is a drug used to treat erectile dysfunction and pulmonary arterial hypertension. It was originally developed by British scientists and then brought to market by the US-based pharmaceutical company Pfizer. It acts by inhibiting cGMP-specific phosphodiesterase type 5, an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis. Since becoming available in 1998, sildenafil has been the prime treatment for erectile dysfunction; its primary competitors on the market are tadalafil and vardenafil.

Matched Categories

1. • Virility Drug

How to pronounce sildenafil?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say sildenafil in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of sildenafil in Chaldean Numerology is: 7

2. Pythagorean Numerology

   The numerical value of sildenafil in Pythagorean Numerology is: 1

Examples of sildenafil in a Sentence

1. Feixiong Cheng:

   Notably, we found that sildenafil use reduced the likelihood of Alzheimer’s in individuals with coronary artery disease, hypertension and type 2 diabetes, all of which are comorbidities significantly associated with risk of the disease, as well as in those without.

2. Feixiong Cheng:

   Because our findings only establish an association between sildenafil use and reduced incidence of Alzheimer’s disease, we are now planning a mechanistic trial and a phase II randomized clinical trial to test causality and confirm sildenafil’s clinical benefits for Alzheimer’s patients.

Popularity rank by frequency of use

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=sildenafil
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Sildenafil
3. ^ Wikipedia
   https://en.wikipedia.org/wiki/Sildenafil
4. ^ ChatGPT
   https://chat.openai.com
5. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=sildenafil