What does siderocalin mean?
Definitions for siderocalin
side·ro·calin
This dictionary definitions page includes all the possible meanings, example usage and translations of the word siderocalin.
Wiktionary
siderocalinnoun
A protein, produced in the body following bacterial infection, that acts against siderophores
Wikipedia
Siderocalin
Siderocalin (Scn), lipocalin-2, NGAL, 24p3 is a mammalian lipocalin-type protein that can prevent iron acquisition by pathogenic bacteria by binding siderophores, which are iron-binding chelators made by microorganisms.Iron serves as a key nutrient in host-pathogen interactions, and pathogens can acquire iron from the host organism via synthesis and release siderophores such as enterobactin. Siderocalin is a part of the mammalian defence mechanism and acts as an antibacterial agent.Crystallographic studies of Scn demonstrated that it includes a calyx, a ligand-binding domain that is lined with polar cationic groups. Central to the siderophore/siderocalin recognition mechanism are hybrid electrostatic/cation-pi interactions. To evade the host defences, pathogens evolved to produce structurally varied siderophores that would not be recognized by siderocalin, allowing the bacteria to acquire iron.
Wikidata
Siderocalin
Siderocalin is a protein that is produced by the body in response to bacterial infection. During an infection, bacteria produce iron-chelators called siderophores, which are used for 'stealing' iron from the host. E. coli, for example, produces a catecholate type of siderophore called Enterobactin that binds iron strongly. Siderocalin has been shown to bind ferric-catecholates, one of which is enterobactin and hence prevents the iron from being delivered to the bacteria. It thus can be seen as part of an innate immune response for protection against infection.
Numerology
Chaldean Numerology
The numerical value of siderocalin in Chaldean Numerology is: 8
Pythagorean Numerology
The numerical value of siderocalin in Pythagorean Numerology is: 1
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"siderocalin." Definitions.net. STANDS4 LLC, 2024. Web. 19 Apr. 2024. <https://www.definitions.net/definition/siderocalin>.
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