Definitions for sideroblast
sider·ob·last

Princeton's WordNetRate this definition:0.0 / 0 votes

1. sideroblastnoun

   an erythroblast having granules of ferritin

WiktionaryRate this definition:0.0 / 0 votes

1. sideroblastnoun

   One of the nucleated erythrocytes with iron granules in their cytoplasm seen in cases of sideroblastic anaemia.

2. Etymology: sidero- + -blast

WikipediaRate this definition:0.0 / 0 votes

1. sideroblast

   Sideroblastic anemia, or sideroachrestic anemia, is a form of anemia in which the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes). In sideroblastic anemia, the body has iron available but cannot incorporate it into hemoglobin, which red blood cells need in order to transport oxygen efficiently. The disorder may be caused either by a genetic disorder or indirectly as part of myelodysplastic syndrome, which can develop into hematological malignancies (especially acute myeloid leukemia). Sideroblasts (sidero- + -blast) are nucleated erythroblasts (precursors to mature red blood cells) with granules of iron accumulated in the mitochondria surrounding the nucleus. Normally, sideroblasts are present in the bone marrow, and enter the circulation after maturing into a normal erythrocyte. The presence of sideroblasts per se does not define sideroblastic anemia. Only the finding of ring (or ringed) sideroblasts characterizes sideroblastic anemia. Ring sideroblasts are named so because iron-laden mitochondria form a ring around the nucleus. It is a subtype of basophilic granules of the erythrocyte, but which can only be seen in bone marrow. To count a cell as a ring sideroblast, the ring must encircle a third or more of the nucleus and contain five or more iron granules, according to the 2008 WHO classification of the tumors of the hematopoietic and lymphoid tissues.

ChatGPTRate this definition:0.0 / 0 votes

1. sideroblast

   A sideroblast is a developing red blood cell that contains granules of iron in its cytoplasm. These iron granules are usually present due to the cell's attempt to incorporate iron into the heme molecule, a component of hemoglobin. If a shortage or dysfunction occurs in the process of developing hemoglobin, these granules can accumulate in the cell, forming a ring around the nucleus and leading to the creation of a ringed sideroblast. This is often associated with certain types of anemias, particularly sideroblastic anemia.

Matched Categories

1. • Erythroblast

How to pronounce sideroblast?

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Numerology

1. Chaldean Numerology

   The numerical value of sideroblast in Chaldean Numerology is: 8

2. Pythagorean Numerology

   The numerical value of sideroblast in Pythagorean Numerology is: 7

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=sideroblast
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Sideroblast
3. ^ Wikipedia
   https://en.wikipedia.org/wiki/Sideroblast
4. ^ ChatGPT
   https://chat.openai.com