What does shelterin mean?

Definitions for shelterin

This dictionary definitions page includes all the possible meanings, example usage and translations of the word shelterin.

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  1. Shelterin

    Shelterin (also called telosome) is a protein complex known to protect telomeres in many eukaryotes from DNA repair mechanisms, as well as to regulate telomerase activity. In mammals and other vertebrates, telomeric DNA consists of repeating double-stranded 5'-GGGTTA-3' (G-strand) sequences (2-15 kilobases in humans) along with the 3'-TAACCC-5' (C-strand) complement, ending with a 50-400 nucleotide 3' (G-strand) overhang. Much of the final double-stranded portion of the telomere forms a T-loop (Telomere-loop) that is invaded by the 3' (G-strand) overhang to form a small D-loop (Displacement-loop).The absence of shelterin causes telomere uncapping and thereby activates damage-signaling pathways that may lead to non-homologous end joining (NHEJ), homology directed repair (HDR), end-to-end fusions, genomic instability, senescence, or apoptosis.

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  1. Chaldean Numerology

    The numerical value of shelterin in Chaldean Numerology is: 6

  2. Pythagorean Numerology

    The numerical value of shelterin in Pythagorean Numerology is: 2


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"shelterin." Definitions.net. STANDS4 LLC, 2023. Web. 27 Mar. 2023. <https://www.definitions.net/definition/shelterin>.

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    joint that forms a corner; usually both sides are bevelled at a 45-degree angle to form a 90-degree corner
    • A. lumberman
    • B. mitre
    • C. muddle
    • D. hunch

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