Definitions for senile plaques
se·nile plaques

WikipediaRate this definition:0.0 / 0 votes

1. senile plaques

   Amyloid plaques (also known as neuritic plaques, amyloid beta plaques or senile plaques) are extracellular deposits of the amyloid beta (Aβ) protein mainly in the grey matter of the brain. Degenerative neuronal elements and an abundance of microglia and astrocytes can be associated with amyloid plaques. Some plaques occur in the brain as a result of aging, but large numbers of plaques and neurofibrillary tangles are characteristic features of Alzheimer's disease. Abnormal neurites in amyloid plaques are tortuous, often swollen axons and dendrites. The neurites contain a variety of organelles and cellular debris, and many of them include characteristic paired helical filaments, the ultrastructural component of neurofibrillary tangles. The plaques are highly variable in shape and size; in tissue sections immunostained for Aβ, they comprise a log-normal size distribution curve with an average plaque area of 400-450 square micrometers (µm²). The smallest plaques (less than 200 µm²), which often consist of diffuse deposits of Aβ, are particularly numerous. The apparent size of plaques is influenced by the type of stain used to detect them, and by the plane through which they are sectioned for analysis under the microscope. Plaques form when Aβ misfolds and aggregates into oligomers and longer polymers, the latter of which are characteristic of amyloid. Misfolded and aggregated Aβ is thought to be neurotoxic, especially in its oligomeric state.

WikidataRate this definition:0.0 / 0 votes

1. Senile plaques

   Senile plaques are extracellular deposits of beta amyloid in the gray matter of the brain. Degenerative neural structures and an abundance of microglia and astrocytes can be associated with senile plaque deposits. These deposits can also be a byproduct of senescence or biological aging. However, large numbers of senile plaques and neurofibrillary tangles are characteristic features of Alzheimer's disease. Abnormal neurites in senile plaques are composed primarily of paired helical filaments, a component of neurofibrillary tangles. The plaques are variable in shape and size, but are on average 50 µm in size. In Alzheimer's disease they are primarily composed of beta amyloid peptides. These polypeptides tend to aggregate and are believed to be neurotoxic.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Senile Plaques

   Spherical masses consisting of amyloid fibrils and neuronal processes.

How to pronounce senile plaques?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

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   Fred

   US English

   Tessa

   South African

How to say senile plaques in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of senile plaques in Chaldean Numerology is: 4

2. Pythagorean Numerology

   The numerical value of senile plaques in Pythagorean Numerology is: 2

References

1. ^ Wikipedia
   https://en.wikipedia.org/wiki/Senile_Plaques
2. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=senile plaques