What does representation oligonucleotide microarray analysis mean?
Definitions for representation oligonucleotide microarray analysis
rep·re·sen·ta·tion oligonu·cleotide mi·croar·ray ana·ly·sis
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Wikidata
Representation oligonucleotide microarray analysis
Representational oligonucleotide microarray analysis is a technique that was developed by Michael Wigler and Rob Lucito at the Cold Spring Harbor Laboratory in 2003. Wigler and Lucito currently run laboratories at CSHL using ROMA to explore genomic copy number variation in cancer and other genetic diseases. In this technique, two genomes are compared for their differences in copy number on a microarray. The ROMA technology emerged from a previous method called Representational Difference Analysis. ROMA, in comparison to other comparative genomic hybridization techniques, has the advantage of reducing the complexity of a genome with a restriction enzyme which highly increases the efficiency of genomic fragment hybridization to a microarray. In ROMA, a genome is digested with a restriction enzyme, ligated with adapters specific to the restriction fragment sticky ends and amplified by PCR. After the PCR step, representations of the entire genome are amplified to pronounce relative increases, decreases or preserve equal copy number in the two genomes. The representations of the two different genomes are labeled with different fluorophores and co-hybridized to a microarray with probes specific to locations across the entire human genome. After analysis of the ROMA microarray image is completed, a copy number profile of the entire human genome is generated. This allows researchers to detect with high accuracy amplifications and deletions that occur across the entire genome.
Numerology
Chaldean Numerology
The numerical value of representation oligonucleotide microarray analysis in Chaldean Numerology is: 1
Pythagorean Numerology
The numerical value of representation oligonucleotide microarray analysis in Pythagorean Numerology is: 8
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