Definitions for quelling
quelling

Princeton's WordNetRate this definition:0.0 / 0 votes

1. suppression, crushing, quelling, stiflingnoun

   forceful prevention; putting down by power or authority

   "the suppression of heresy"; "the quelling of the rebellion"; "the stifling of all dissent"

WikipediaRate this definition:0.0 / 0 votes

1. quelling

   RNA interference (RNAi) is a biological process in which RNA molecules are involved in sequence-specific suppression of gene expression by double-stranded RNA, through translational or transcriptional repression. Historically, RNAi was known by other names, including co-suppression, post-transcriptional gene silencing (PTGS), and quelling. The detailed study of each of these seemingly different processes elucidated that the identity of these phenomena were all actually RNAi. Andrew Fire and Craig C. Mello shared the 2006 Nobel Prize in Physiology or Medicine for their work on RNAi in the nematode worm Caenorhabditis elegans, which they published in 1998. Since the discovery of RNAi and its regulatory potentials, it has become evident that RNAi has immense potential in suppression of desired genes. RNAi is now known as precise, efficient, stable and better than antisense therapy for gene suppression. Antisense RNA produced intracellularly by an expression vector may be developed and find utility as novel therapeutic agents.Two types of small ribonucleic acid (RNA) molecules, microRNA (miRNA) and small interfering RNA (siRNA), are central to components to the RNAi pathway. Once mRNA is degraded, post-transcriptional silencing occurs as protein translation is prevented. Transcription can be inhibited via the pre-transcriptional silencing mechanism of RNAi, through which an enzyme complex catalyzes DNA methylation at genomic positions complementary to complexed siRNA or miRNA. RNAi has an important role in defending cells against parasitic nucleotide sequences (e.g., viruses or transposons) and also influences development of organisms. The RNAi pathway is a naturally occurring process found in many eukaryotes and animal cells. It is initiated by the enzyme Dicer, which cleaves long double-stranded RNA (dsRNA) molecules into short double-stranded fragments of approximately 21 to 23 nucleotide siRNAs. Each siRNA is unwound into two single-stranded RNAs (ssRNAs), the passenger (sense) strand and the guide (antisense) strand. The passenger strand is then cleaved by the protein Argonaute 2 (Ago2). The passenger strand is degraded and the guide strand is incorporated into the RNA-induced silencing complex (RISC). The RISC assembly then binds and degrades the target mRNA. Specifically, this is accomplished when the guide strand pairs with a complementary sequence in a mRNA molecule and induces cleavage by Ago2, a catalytic component of the RISC. In some organisms, this process spreads systemically, despite the initially limited molar concentrations of siRNA.RNAi is a valuable research tool, both in cell culture and in living organisms, because synthetic dsRNA introduced into cells can selectively and robustly induce suppression of specific genes of interest. RNAi may be used for large-scale screens that systematically shut down each gene (and the subsequent proteins it codes for) in the cell, which can help to identify the components necessary for a particular cellular process or an event such as cell division. The pathway is also used as a practical tool for food, medicine and insecticides.

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1. quelling

   Quelling refers to the act of suppressing or putting an end to something forcefully, usually a disturbance, resistance, rebellion, or emotions. It involves calming, quieting, or pacifying a situation or person.

Webster DictionaryRate this definition:0.0 / 0 votes

1. Quelling

   of Quell

Matched Categories

1. • Prevention

How to pronounce quelling?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say quelling in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of quelling in Chaldean Numerology is: 9

2. Pythagorean Numerology

   The numerical value of quelling in Pythagorean Numerology is: 7

Examples of quelling in a Sentence

1. Jennifer Kertanis:

   One of the things that local health departments and state health departments are really doing is trying to make sure that we're getting the best information out so that we're quelling fear but at the same time leaning forward and preparing people as this continues to grow and develop.

2. Mark Milley:

   We never introduced federal troops on the streets of America as a result of the combined efforts of the National Guard and law enforcement at quelling the violence and de-escalating very very tense situations.

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