Definitions for protein folding
pro·tein fold·ing

Princeton's WordNetRate this definition:0.0 / 0 votes

1. protein folding, foldingnoun

   the process whereby a protein molecule assumes its intricate three-dimensional shape

   "understanding protein folding is the next step in deciphering the genetic code"

WikipediaRate this definition:0.0 / 0 votes

1. Protein folding

   Protein folding is the physical process by which a protein chain is translated into its native three-dimensional structure, typically a "folded" conformation, by which the protein becomes biologically functional. Via an expeditious and reproducible process, a polypeptide folds into its characteristic three-dimensional structure from a random coil. Each protein exists first as an unfolded polypeptide or random coil after being translated from a sequence of mRNA into a linear chain of amino acids. At this stage, the polypeptide lacks any stable (i.e., long-lasting) three-dimensional structure (see the left side of the first figure). As the polypeptide chain is being synthesized by a ribosome, the linear chain begins to fold into its three-dimensional structure. The folding of many proteins begins even during the translation of the polypeptide chain. The amino acids interact with each other to produce a well-defined three-dimensional structure, the folded protein (see the right side of the figure), known as the native state. The resulting three-dimensional structure is determined by the amino-acid sequence or primary structure (e.g., Anfinsen's dogma).The correct three-dimensional structure is essential to function, although some parts of functional proteins may remain unfolded, indicating that protein dynamics are important. Failure to fold into a native structure generally produces inactive proteins, but in some instances, misfolded proteins have modified or toxic functionality. Several neurodegenerative and other diseases are believed to result from the accumulation of amyloid fibrils formed by misfolded proteins, the infectious varieties of which are known as prions. Many allergies are caused by incorrect folding of some proteins because the immune system does not produce the antibodies for certain protein structures.Denaturation of proteins is a process of transition from a folded to an unfolded state. It happens in cooking, burns, proteinopathies, and other contexts. The duration of the folding process varies dramatically depending on the protein of interest. When studied outside the cell, the slowest folding proteins require many minutes or hours to fold, primarily due to proline isomerization, and must pass through a number of intermediate states, like checkpoints, before the process is complete. On the other hand, very small single-domain proteins with lengths of up to a hundred amino acids typically fold in a single step. Time scales of milliseconds are the norm, and the fastest known protein folding reactions are complete within a few microseconds. The folding time scale of a protein depends on its size, contact order, and circuit topology.Understanding and simulating the protein folding process has been an important challenge for computational biology since the late 1960s.

ChatGPTRate this definition:0.0 / 0 votes

1. protein folding

   Protein folding is the biological process by which a protein chain acquires its three-dimensional structure, a conformation that is usually biologically functional, in an expeditious and precise manner. This structure is determined by the sequence of amino acids that make up the protein. The correct folding of a protein is vital to its function, and misfolded proteins can lead to numerous health disorders, including neurodegenerative diseases.

WikidataRate this definition:0.0 / 0 votes

1. Protein folding

   Protein folding is the process by which a protein structure assumes its functional shape or conformation. It is the physical process by which a polypeptide folds into its characteristic and functional three-dimensional structure from random coil. Each protein exists as an unfolded polypeptide or random coil when translated from a sequence of mRNA to a linear chain of amino acids. This polypeptide lacks any stable three-dimensional structure. Amino acids interact with each other to produce a well-defined three-dimensional structure, the folded protein, known as the native state. The resulting three-dimensional structure is determined by the amino acid sequence. Experiments beginning in the 1980s indicate the codon for an amino acid can also influence protein structure. The correct three-dimensional structure is essential to function, although some parts of functional proteins may remain unfolded. Failure to fold into native structure generally produces inactive proteins, but in some instances misfolded proteins have modified or toxic functionality. Several neurodegenerative and other diseases are believed to result from the accumulation of amyloid fibrils formed by misfolded proteins. Many allergies are caused by incorrect folding of some proteins, for the immune system does not produce antibodies for certain protein structures.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Protein Folding

   A rapid biochemical reaction involved in the formation of proteins. It begins even before a protein has been completely synthesized and proceeds through discrete intermediates (primary, secondary, and tertiary structures) before the final structure (quaternary structure) is developed.

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1. • Organic Process

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Numerology

1. Chaldean Numerology

   The numerical value of protein folding in Chaldean Numerology is: 9

2. Pythagorean Numerology

   The numerical value of protein folding in Pythagorean Numerology is: 2

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=protein folding
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Protein_Folding
3. ^ ChatGPT
   https://chat.openai.com
4. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=protein folding