What does proliferating cell nuclear antigen mean?
Definitions for proliferating cell nuclear antigen
pro·lif·er·at·ing cell nucle·ar anti·gen
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Wikidata
Proliferating cell nuclear antigen
Proliferating cell nuclear antigen is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where is acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin remodeling and epigenetics. Many proteins interact with PCNA via the two known PCNA-interacting motifs PCNA-interacting peptide box and AlkB homologue 2 PCNA interacting motif. Proteins binding to PCNA via the PIP-box are mainly involved in DNA replication whereas proteins binding to PCNA via APIM is mainly important in the context of genotoxic stress. The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.
U.S. National Library of Medicine
Proliferating Cell Nuclear Antigen
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Numerology
Chaldean Numerology
The numerical value of proliferating cell nuclear antigen in Chaldean Numerology is: 5
Pythagorean Numerology
The numerical value of proliferating cell nuclear antigen in Pythagorean Numerology is: 2
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"proliferating cell nuclear antigen." Definitions.net. STANDS4 LLC, 2024. Web. 24 Apr. 2024. <https://www.definitions.net/definition/proliferating+cell+nuclear+antigen>.
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