What does proglumide mean?
Definitions for proglumide
prog·lu·mide
This dictionary definitions page includes all the possible meanings, example usage and translations of the word proglumide.
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Wiktionary
proglumidenoun
A cholecystokinin antagonist drug that inhibits gastrointestinal motility and reduces gastric secretions.
Wikidata
Proglumide
Proglumide is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers, although it has now been largely replaced by newer drugs for this application. An interesting side effect of proglumide is that it enhances the analgesia produced by opioid drugs, and can prevent or even reverse the development of tolerance to opioid drugs. This can make it a useful adjuvant treatment to use alongside opioid drugs in the treatment of chronic pain conditions such as cancer, where opioid analgesics may be required for long periods and development of tolerance reduces clinical efficacy of these drugs. Proglumide has also been shown to act as a δ-opioid agonist, which may contribute to its analgesic effects. Proglumide also works as a placebo effect amplifier for pain conditions. When injected visibly to a subject, its analgesic effect is bigger than a similarly administered placebo. When injected secretly, it does not have any effect, whereas standard pain drugs have an effect, even if they are administered without the subject's awareness. The supposed mechanism is an enhancement of the neural pathways of expectation.
U.S. National Library of Medicine
Proglumide
A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.
Numerology
Chaldean Numerology
The numerical value of proglumide in Chaldean Numerology is: 7
Pythagorean Numerology
The numerical value of proglumide in Pythagorean Numerology is: 3
Translations for proglumide
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"proglumide." Definitions.net. STANDS4 LLC, 2024. Web. 24 Apr. 2024. <https://www.definitions.net/definition/proglumide>.
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