What does polar surface area mean?

Definitions for polar surface area
po·lar sur·face area

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Wikipedia

  1. Polar surface area

    The polar surface area (PSA) or topological polar surface area (TPSA) of a molecule is defined as the surface sum over all polar atoms or molecules, primarily oxygen and nitrogen, also including their attached hydrogen atoms. PSA is a commonly used medicinal chemistry metric for the optimization of a drug's ability to permeate cells. Molecules with a polar surface area of greater than 140 angstroms squared tend to be poor at permeating cell membranes. For molecules to penetrate the blood–brain barrier (and thus act on receptors in the central nervous system), a PSA less than 90 angstroms squared is usually needed.

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Numerology

  1. Chaldean Numerology

    The numerical value of polar surface area in Chaldean Numerology is: 4

  2. Pythagorean Numerology

    The numerical value of polar surface area in Pythagorean Numerology is: 7


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"polar surface area." Definitions.net. STANDS4 LLC, 2024. Web. 24 Apr. 2024. <https://www.definitions.net/definition/polar+surface+area>.

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