Definitions for piebaldism
piebald·ism

WiktionaryRate this definition:0.0 / 0 votes

1. piebaldismnoun

   A rare autosomal dominant disorder of melanocyte development, whose common characteristics include a congenital white forelock, scattered normally-pigmented and hyperpigmented macules, and a triangular depigmented patch on the forehead.

WikidataRate this definition:0.0 / 0 votes

1. Piebaldism

   Piebaldism is a rare autosomal dominant disorder of melanocyte development. Common characteristics include a congenital white forelock, scattered normal pigmented and hypopigmented macules and a triangular shaped depigmented patch on the forehead. Although piebaldism may visually appear to be partial albinism, it is a fundamentally different condition. The vision problems associated with albinism are not usually present as eye pigmentation is normal. Piebaldism differs from albinism in that the affected cells maintain the ability to produce pigment but have that specific function turned off. In albinism the cells lack the ability to produce pigment altogether. It may be associated with KIT or SNAI2.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Piebaldism

   Autosomal dominant, congenital disorder characterized by localized hypomelanosis of the skin and hair. The most familiar feature is a white forelock presenting in 80 to 90 percent of the patients. The underlying defect is possibly related to the differentiation and migration of melanoblasts, as well as to defective development of the neural crest (neurocristopathy). Piebaldism may be closely related to Waardenburg's syndrome.

Anagrams for piebaldism »

1. bipedalism

How to pronounce piebaldism?

1. Alex

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   David

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   Mark

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   Daniel

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   Libby

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   Karen

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How to say piebaldism in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of piebaldism in Chaldean Numerology is: 5

2. Pythagorean Numerology

   The numerical value of piebaldism in Pythagorean Numerology is: 9

Examples of piebaldism in a Sentence

1. Christian Yates:

   Piebaldism is actually a disease, it's caused by cells in the early embryo failing to migrate correctly.... failing to get to the right place. The cells which we're interested in, that cause piebaldism, are called melanocytes and they're responsible for pigmentation of hair and of the skin. These cells start at the back of the embryo and they try to migrate round through the skin and cover the whole of the( embryo's) skin. When they fail to do that properly you tend to get regions of skin or hair which are lacking in pigment, often regions at the front of an animal. This is common in cats...... tuxedo cats, and it's also common in horses and pigs and even in humans.

2. Christian Yates:

   By trying to understand piebaldism, which doesn't have a particularly severe manifestation, so it's just a change in pigmentation, we can try to use the same techniques that we've developed to try and model and understand these other more serious diseases, which effectively are caused by similar mechanisms - cells not migrating properly in the early embryo.

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Piebaldism
2. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=piebaldism