Definitions for pharmacogenomic
phar·ma·coge·nom·ic

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1. pharmacogenomicadjective

   Of or pertaining to pharmacogenomics

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1. pharmacogenomic

   Pharmacogenomics is the study of the role of the genome in drug response. Its name (pharmaco- + genomics) reflects its combining of pharmacology and genomics. Pharmacogenomics analyzes how the genetic makeup of an individual affects their response to drugs. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating DNA mutations (including single-nucleotide polymorphisms, copy number variations, and insertions/deletions) with pharmacokinetic (drug absorption, distribution, metabolism, and elimination), pharmacodynamic (effects mediated through a drug's biological targets), and/or immunogenic endpoints.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficiency with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that pharmaceutical drug treatments can deviate from what is dubbed as the "one-dose-fits-all" approach. Pharmacogenomics also attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient's genes, the functionality of these genes, and how this may affect the efficacy of the patient's current or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of precision medicine and even personalized medicine, in which drugs and drug combinations are optimized for narrow subsets of patients or even for each individual's unique genetic makeup.Whether used to explain a patient's response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).

How to pronounce pharmacogenomic?

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How to say pharmacogenomic in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of pharmacogenomic in Chaldean Numerology is: 5

2. Pythagorean Numerology

   The numerical value of pharmacogenomic in Pythagorean Numerology is: 6

Examples of pharmacogenomic in a Sentence

1. Carl Higbie:

   For this test to become mainstream it would A.) save lives and B.) save the VA probably billions in dollars in overmedication costs, and yet they’re not doing it and it’s like leaving your brothers out to dry, the overwhelming consensus of the pharmacogenomic community is that most of these tests currently lack evidence of clinical effectiveness. That means they have not shown to have better outcomes over the usual methods of drug prescription, with some exceptions. Many commercial tests target psychiatric disease therapy and pain management. One recent VA review documented that these tests do not yet have evidence for utility, especially in the veteran population.

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Pharmacogenomic
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Pharmacogenomic