Definitions for pernicious anemia
per·ni·cious ane·mi·a

Princeton's WordNetRate this definition:0.0 / 0 votes

1. pernicious anemia, pernicious anaemia, malignant anemia, malignant anaemianoun

   a chronic progressive anemia of older adults; thought to result from a lack of intrinsic factor (a substance secreted by the stomach that is responsible for the absorption of vitamin B12)

WiktionaryRate this definition:0.0 / 0 votes

1. pernicious anemianoun

   A severe form of anemia caused by vitamin B insufficiency.

WikipediaRate this definition:0.0 / 0 votes

1. Pernicious anemia

   Pernicious anemia is a type of vitamin B12 deficiency anemia, a disease in which not enough red blood cells are produced due to the malabsorption of vitamin B12. Malabsorption in pernicious anemia results from the lack or loss of intrinsic factor needed for the absorption of vitamin B12. Anemia is defined as a condition in which the blood has a lower than normal amount of red blood cells or hemoglobin. The onset can be gradual and no changes can be observed for a period of time.The most common initial symptoms are tiredness, and weakness. Other signs and symptoms of anemia include breathlessness, dizziness, a sore red tongue, lightheadedness, headaches, poor ability to exercise, cold hands and feet, low blood pressure, pale or yellow skin, chest pain, and an irregular heartbeat. The digestive tract may also be disturbed giving symptoms that can include nausea and vomiting, heartburn, upset stomach and loss of appetite. Pernicious anemia can cause osteoporosis and may lead to bone fractures. Symptoms of vitamin B12 deficiency can include numbness in the hands and feet, memory problems, blurred vision, trouble walking, poor balance, muscle weakness, impaired sense of taste and smell, poor reflexes, clumsiness, depression, and confusion. Without treatment, some of these problems may become permanent.Pernicious anemia occurs due to an autoimmune response that produces antibodies that attack the parietal cells in the stomach lining and prevents them from creating intrinsic factor. Malabsorption may also result from the surgical removal of all or part of the stomach or small intestine; from an inherited disorder or illnesses that damage the stomach lining. When suspected, diagnosis is made by blood tests initially a complete blood count, and occasionally, bone marrow tests. Blood tests may show fewer but larger red blood cells, low numbers of young red blood cells, low levels of vitamin B12, and antibodies to intrinsic factor.Pernicious anemia can be treated with intramuscular injections or pills of vitamin B12. Nasal sprays and gels are also available for those who have trouble swallowing pills. Treatment may need to be lifelong.Pernicious anemia due to autoimmune problems occurs in about one per 1000 people in the USA. Among those over the age of 60, about 2% have the condition. It more commonly affects people of northern European descent. Women are more commonly affected than men. With proper treatment, most people live normal lives. Due to a higher risk of stomach cancer, those with pernicious anemia should be checked regularly for this. The first clear description was by Thomas Addison in 1849. The term "pernicious" means "deadly", and this term came into use because, before the availability of treatment, the disease was often fatal.

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1. pernicious anemia

   Pernicious anemia is a type of anemia that occurs when the body is unable to absorb vitamin B12 from the digestive tract, due to a lack of intrinsic factor in the stomach. Vitamin B12 is necessary for the production of healthy red blood cells. Pernicious anemia is a chronic illness that can lead to damage in the nerves and other organs if not treated early. Symptoms include fatigue, shortness of breath, rapid heartbeat, loss of appetite, neurological issues like numbness or tingling in the hands and feet, and difficulty maintaining balance. It is most common among older people and in people of northern European and African descent.

WikidataRate this definition:0.0 / 0 votes

1. Pernicious anemia

   Pernicious anemia is one of many types of the larger family of megaloblastic anemias. It is caused by loss of gastric parietal cells, which are responsible, in part, for the secretion of intrinsic factor, a protein essential for subsequent absorption of vitamin B12 in the ileum. Usually seated in an atrophic gastritis, the autoimmune destruction of gastric parietal cells leads to a lack of intrinsic factor. Since the absorption from the gut of normal dietary amounts of vitamin B12 is dependent on intrinsic factor, the loss of intrinsic factor leads to vitamin B12 deficiency. While the term 'pernicious anemia' is sometimes also incorrectly used to indicate megaloblastic anemia due to any cause of B12 deficiency, its proper usage refers to that caused by atrophic gastritis, parietal cell loss, and lack of intrinsic factor only. The loss of ability to absorb vitamin B12 is the most common cause of adult B12 deficiency. Impaired absorption of vitamin B12 may be due to a loss of intrinsic factor or to a number of other conditions that decrease production of gastric acid, which also plays a part in the absorption of B12 from foods.

Matched Categories

1. • Anemia

How to pronounce pernicious anemia?

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Numerology

1. Chaldean Numerology

   The numerical value of pernicious anemia in Chaldean Numerology is: 4

2. Pythagorean Numerology

   The numerical value of pernicious anemia in Pythagorean Numerology is: 1

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=pernicious anemia
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Pernicious_Anemia
3. ^ Wikipedia
   https://en.wikipedia.org/wiki/Pernicious_Anemia
4. ^ ChatGPT
   https://chat.openai.com
5. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=pernicious anemia