Definitions for periventricular leukomalacia
periven·tric·u·lar leuko·ma·la·cia

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1. Periventricular leukomalacia

   Periventricular leukomalacia (PVL) is a form of white-matter brain injury, characterized by the necrosis (more often coagulation) of white matter near the lateral ventricles. It can affect newborns and (less commonly) fetuses; premature infants are at the greatest risk of neonatal encephalopathy which may lead to this condition. Affected individuals generally exhibit motor control problems or other developmental delays, and they often develop cerebral palsy or epilepsy later in life. The white matter in preterm born children is particularly vulnerable during the third trimester of pregnancy when white matter developing takes place and the myelination process starts around 30 weeks of gestational age.This pathology of the brain was described under various names ("encephalodystrophy", "ischemic necrosis", "periventricular infarction", "coagulation necrosis", "leukomalacia," "softening of the brain", "infarct periventricular white matter", "necrosis of white matter", "diffuse symmetrical periventricular leukoencephalopathy"), and more often by German scientists, but the worldwide dissemination was the term periventricular leukomalacia, introduced in 1962 B. A. Banker and J. C. Larroche. The term can be misleading, because there is no softening of the tissue in PVL. Vlasyuk and Tumanov in 1985 published the world's first monograph devoted to PVL. Vlasyuk (1981) first revealed the high incidence of optic radiation lesions and demonstrated that PVL is a persistent process where old necrosis can join new foci of PVL at different stages of development. In the process of morphogenesis focuses PVL pass through three stages: 1) necrosis, 2) resorption, and 3) the formation gliosis scars or cysts. Cysts occur when large and confluent focuses of PVL, with mixed necrosis (kollikvacia in the center and coagulation rim at the periphery). Around the foci is generally defined area of other lesions of the brain white matter - the death of prooligodendrocytes, proliferation mikrogliocytes and astrocytes, swelling, bleeding, loss of capillaries, and others (the so-called "diffuse component PVL"). However, diffuse lesions without necrosis are not PVL.

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1. Periventricular leukomalacia

   Periventricular leukomalacia is a form of white-matter brain injury, characterized by the necrosis of white matter near the lateral ventricles. It can affect newborns and fetuses; premature infants are at the greatest risk of the disorder. Affected individuals generally exhibit motor control problems or other developmental delays, and they often develop cerebral palsy or epilepsy later in life. This pathology of the brain was described under various names, and more often by German scientists, but the worldwide dissemination was the term «periventricular leukomalacia», introduced in 1962 B.A.Banker and J.C.Larroche. The term is not clear, since there are no softening of PVL, and more dense than surrounding areas of the brain foci of coagulation necrosis. V.V. Vlasyuk and V.P. Tumanov in 1985 published the world's first monograph devoted to PVL. The most comprehensive study of PVL in the world at the largest section material held V.V. Vlasyuk, who first revealed the high incidence of optic radiation lesions and demonstrated that PVL - a persistent process that the old necrosis can join a new, foci of PVL may be at different stages of development. In the process of morphogenesis focuses PVL pass through three stages: 1 necrosis, 2 resorption, and 3 the formation gliosis scars or cysts. Cysts occur when large and confluent focuses of PVL, with mixed necrosis. Around the foci is generally defined area of other lesions of the brain white matter - the death of prooligodendrocytes, proliferation mikrogliocytes and astrocytes, swelling, bleeding, loss of capillaries, and others. However, diffuse lesions without necrosis are not PVL.

How to pronounce periventricular leukomalacia?

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Numerology

1. Chaldean Numerology

   The numerical value of periventricular leukomalacia in Chaldean Numerology is: 1

2. Pythagorean Numerology

   The numerical value of periventricular leukomalacia in Pythagorean Numerology is: 7

References

1. ^ Wikipedia
   https://en.wikipedia.org/wiki/Periventricular_Leukomalacia
2. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=periventricular leukomalacia