What does peptide t mean?
Definitions for peptide t
pep·tide t
This dictionary definitions page includes all the possible meanings, example usage and translations of the word peptide t.
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Wikidata
Peptide T
Peptide T is an HIV entry inhibitor discovered in 1986 by National Institutes of Health researchers. Peptide T, and its modified analog Dala1-peptide T-amide, a drug in clinical trials, is a short peptide derived from the HIV envelope protein gp120 which blocks binding and infection of viral strains which use the CCR5 receptor to infect cells. Peptide T has several positive effects related to HIV disease and Neuro-AIDS. A placebo-controlled, three site, 200+ patient NIH-funded clinical trial, which focused on neurocognitive improvements, was conducted between 1990 and 1995. The results showed that peptide T was not significantly different from placebo on the study primary end points. However, peptide T was associated with improved performance in the subgroup of patients with more severe cognitive impairment. A long-delayed analysis of antiviral effects from the 1996 NIH study showed peripheral viral load was significantly reduced in the DAPTA-treated group. An eleven person study for peptide T effects on cellular viral load showed reductions in the persistently infected monocyte reservoir to undetectable levels in most of the patients. Elimination of viral reservoirs, such as the monocytes, is an important treatment goal. DAPTA has been shown to substantially suppress brain inflammation and block proinflammatory cytokine signaling pathways in a small animal model of Alzheimer's disease.
U.S. National Library of Medicine
Peptide T
N-(N-(N(2)-(N-(N-(N-(N-D-Alanyl L-seryl)-L-threonyl)-L-threonyl) L-threonyl)-L-asparaginyl)-L-tyrosyl) L-threonine. Octapeptide sharing sequence homology with HIV envelope protein gp120. It is potentially useful as antiviral agent in AIDS therapy. The core pentapeptide sequence, TTNYT, consisting of amino acids 4-8 in peptide T, is the HIV envelope sequence required for attachment to the CD4 receptor.
Numerology
Chaldean Numerology
The numerical value of peptide t in Chaldean Numerology is: 3
Pythagorean Numerology
The numerical value of peptide t in Pythagorean Numerology is: 5
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"peptide t." Definitions.net. STANDS4 LLC, 2024. Web. 25 Apr. 2024. <https://www.definitions.net/definition/peptide+t>.
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