What does peptide nucleic acid mean?
Definitions for peptide nucleic acid
pep·tide nu·cle·ic acid
This dictionary definitions page includes all the possible meanings, example usage and translations of the word peptide nucleic acid.
Wikidata
Peptide nucleic acid
Peptide nucleic acid is an artificially synthesized polymer similar to DNA or RNA invented by Peter E. Nielsen, Michael Egholm, Rolf H. Berg, and Ole Buchardt in 1991. The name is somewhat of a misnomer as PNA is not an acid. Synthetic peptide nucleic acid oligomers have been used in recent years in molecular biology procedures, diagnostic assays and antisense therapies. Due to their higher binding strength it is not necessary to design long PNA oligomers for use in these roles, which usually require oligonucleotide probes of 20–25 bases. The main concern of the length of the PNA-oligomers is to guarantee the specificity. PNA oligomers also show greater specificity in binding to complementary DNAs, with a PNA/DNA base mismatch being more destabilizing than a similar mismatch in a DNA/DNA duplex. This binding strength and specificity also applies to PNA/RNA duplexes. PNAs are not easily recognized by either nucleases or proteases, making them resistant to enzyme degradation. PNAs are also stable over a wide pH range. Though an unmodified PNA cannot readily cross cell membranes to enter the cytosol, covalently coupling a cell penetrating peptide to a PNA can improve cytosolic delivery.
Numerology
Chaldean Numerology
The numerical value of peptide nucleic acid in Chaldean Numerology is: 7
Pythagorean Numerology
The numerical value of peptide nucleic acid in Pythagorean Numerology is: 6
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"peptide nucleic acid." Definitions.net. STANDS4 LLC, 2024. Web. 23 Apr. 2024. <https://www.definitions.net/definition/peptide+nucleic+acid>.
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