A short sequence of nucleotides (RNA or DNA), typically with twenty or fewer base pairs.
Oligonucleotides are short, single-stranded DNA or RNA molecules that have a wide range of applications in genetic testing, research, and forensics. Commonly made in the laboratory by solid-phase chemical synthesis, these small bits of nucleic acids can be manufactured with any user-specified sequence, and so are vital for artificial gene synthesis, polymerase chain reaction, DNA sequencing, library construction and as molecular probes. In nature, oligonucleotides are usually found as small RNA molecules that function in the regulation of gene expression, or are degradation intermediates derived from the breakdown of larger nucleic acid molecules. Oligonucleotides are characterized by the sequence of nucleotide residues that comprise the entire molecule. The length of the oligonucleotide is usually denoted by "-mer". For example, an oligonucleotide of six nucleotides is an hexamer, while one of 25 nt would usually be called a "25-mer". Oligonucleotides readily bind, in a sequence-specific manner, to their respective complementary oligonucleotides, DNA, or RNA to form duplexes or, less often, hybrids of a higher order. This basic property serves as a foundation for the use of oligonucleotides as probes for detecting DNA or RNA. Examples of procedures that use oligonucleotides include DNA microarrays, Southern blots, ASO analysis, fluorescent in situ hybridization, and the synthesis of artificial genes. Oligonucleotides are also indispensable elements in antisense gene therapy.
The numerical value of oligonucleotide in Chaldean Numerology is: 1
The numerical value of oligonucleotide in Pythagorean Numerology is: 4
Images & Illustrations of oligonucleotide
Translations for oligonucleotide
From our Multilingual Translation Dictionary
Get even more translations for oligonucleotide »
Find a translation for the oligonucleotide definition in other languages:
Select another language:
Discuss these oligonucleotide definitions with the community:
Word of the Day
Would you like us to send you a FREE new word definition delivered to your inbox daily?
Use the citation below to add this definition to your bibliography:
"oligonucleotide." Definitions.net. STANDS4 LLC, 2018. Web. 25 Apr. 2018. <https://www.definitions.net/definition/oligonucleotide>.