Definitions for nesidioblastosis
ne·sid·ioblas·to·sis

WikipediaRate this definition:0.0 / 0 votes

1. Nesidioblastosis

   Nesidioblastosis is a controversial medical term for hyperinsulinemic hypoglycemia attributed to excessive insulin production by pancreatic beta cells that have an abnormal microscopic appearance. The term was coined in the first half of the 20th century. The abnormal microscopic features of the tissue included the presence of islet cell enlargement, pancreatic islet cell dysplasia, beta cells budding from ductal epithelium, and islets in close proximity to ducts. By the 1970s, nesidioblastosis was primarily used to describe the pancreatic dysfunction associated with persistent congenital hyperinsulinism and in most cases from the 1970s until the 1980s it was used as a synonym for what is now referred to as congenital hyperinsulinism. Most congenital hyperinsulinism is now known to be caused by different mechanisms than excessive proliferation of beta cells in a fetal pattern, and the term fell into disfavor after it was recognized in the late 1980s that the characteristic tissue features of nesidioblastosis were sometimes seen in pancreatic tissue from normal infants and even from adults, and are therefore not consistently associated with hyperinsulinemic hypoglycemia.In recent years, the term has been revived to describe a form of acquired hyperinsulinism with beta cell hyperplasia found in adults, especially after gastrointestinal surgery. Evidence of mechanisms explaining the ability of weight loss surgery to induce modern-day nesidioblastosis has yet to be found; any such mechanisms are of intense interest to diabetes researchers.

WikidataRate this definition:0.0 / 0 votes

1. Nesidioblastosis

   Nesidioblastosis is a controversial medical term for hyperinsulinemic hypoglycemia attributed to excessive function of pancreatic beta cells with an abnormal microscopic appearance. The term was coined in the first half of the 20th century. The abnormal histologic aspects of the tissue included the presence of islet cell enlargement, islet cell dysplasia, beta cells budding from ductal epithelium, and islets in apposition to ducts. By the 1970s, nesidioblastosis was primarily used to describe the pancreatic dysfunction associated with persistent congenital hyperinsulinism and in most cases from the 1970s until the 1980s, it was used as a synonym for what is now referred to as congenital hyperinsulinism. Most congenital hyperinsulinism is caused by different mechanisms than excessive proliferation of beta cells in a fetal pattern and the term fell into disfavor after it was recognized in the late 1980s that the characteristic tissue features were sometimes seen in pancreatic tissue from normal infants and even adults, and is not consistently associated with hyperinsulinemic hypoglycemia. However, the term has been resurrected in recent years to describe a form of acquired hyperinsulinism with beta cell hyperplasia found in adults, especially after gastrointestinal surgery.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Nesidioblastosis

   An inherited autosomal recessive syndrome characterized by the disorganized formation of new islets in the PANCREAS and PERSISTENT HYPERINSULINEMIA HYPOGLYCEMIA OF INFANCY. It is due to focal hyperplasia of pancreatic ISLET CELLS budding off from the ductal structures and forming new islets of Langerhans. Mutations in the islet cells involve the potassium channel gene KCNJ11 or the ATP-binding cassette transporter gene ABCC8, both on CHROMOSOME 11.

How to pronounce nesidioblastosis?

1. Alex

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   Mark

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   Daniel

   British

   Libby

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Numerology

1. Chaldean Numerology

   The numerical value of nesidioblastosis in Chaldean Numerology is: 8

2. Pythagorean Numerology

   The numerical value of nesidioblastosis in Pythagorean Numerology is: 2

References

1. ^ Wikipedia
   https://en.wikipedia.org/wiki/Nesidioblastosis
2. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=nesidioblastosis