What does mitophagy mean?

Definitions for mitophagy

This dictionary definitions page includes all the possible meanings, example usage and translations of the word mitophagy.

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  1. Mitophagy

    Mitophagy is the selective degradation of mitochondria by autophagy. It often occurs to defective mitochondria following damage or stress. The process of mitophagy was first described over a hundred years ago by Lewis and Lewis. Ashford and Porter used electron microscopy to observe mitochondrial fragments in liver lysosomes by 1962, and a 1977 report suggested that "mitochondria develop functional alterations which would activate autophagy." The term "mitophagy" was in use by 1998.Mitophagy is key in keeping the cell healthy. It promotes turnover of mitochondria and prevents accumulation of dysfunctional mitochondria which can lead to cellular degeneration. It is mediated by Atg32 (in yeast) and NIX and its regulator BNIP3 in mammals. Mitophagy is regulated by PINK1 and parkin proteins. In addition to the selective removal of damaged mitochondria, mitophagy is also required to adjust mitochondrial numbers to changing cellular metabolic needs, for steady-state mitochondrial turnover, and during certain cellular developmental stages, such as during cellular differentiation of red blood cells.

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  1. Chaldean Numerology

    The numerical value of mitophagy in Chaldean Numerology is: 7

  2. Pythagorean Numerology

    The numerical value of mitophagy in Pythagorean Numerology is: 6

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"mitophagy." Definitions.net. STANDS4 LLC, 2023. Web. 23 Sep. 2023. <https://www.definitions.net/definition/mitophagy>.

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