Definitions for microrna
mi·cror·na

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1. microRNAnoun

   A single-stranded, non-coding form of RNA, having only about 20-30 nucleotides, that has a number of functions including the regulation of gene expression

2. Etymology: From micro- + RNA

WikipediaRate this definition:0.0 / 0 votes

1. MicroRNA

   MicroRNA (miRNA) are small, single-stranded, non-coding RNA molecules containing 21 to 23 nucleotides. Found in plants, animals and some viruses, miRNAs are involved in RNA silencing and post-transcriptional regulation of gene expression. miRNAs base-pair to complementary sequences in mRNA molecules, then gene silence said mRNA molecules by one or more of the following processes: (1) cleavage of mRNA strand into two pieces, (2) destabilization of mRNA by shortening its poly(A) tail, or (3) translation of mRNA into proteins. This last method of gene silencing is the least efficient of the three, and requires the aid of ribosomes.miRNAs resemble the small interfering RNAs (siRNAs) of the RNA interference (RNAi) pathway, except miRNAs derive from regions of RNA transcripts that fold back on themselves to form short hairpins, whereas siRNAs derive from longer regions of double-stranded RNA. The human genome may encode over 1900 miRNAs, although more recent analysis suggests that the number is closer to 2,300. However, only about 500 human microRNAs represent bona fide miRNA in the manually curated miRNA gene database MirGeneDB.miRNAs are abundant in many mammalian cell types and as extracellular circulating miRNAs. Circulating miRNAs are released into body fluids including blood and cerebrospinal fluid and have the potential to be available as biomarkers in a number of diseases. MiRNAs appear to target about 60% of the genes of humans and other mammals. Many miRNAs are evolutionarily conserved, which implies that they have important biological functions. For example, 90 families of miRNAs have been conserved since at least the common ancestor of mammals and fish, and most of these conserved miRNAs have important functions, as shown by studies in which genes for one or more members of a family have been knocked out in mice.

WikidataRate this definition:0.0 / 0 votes

1. microRNA

   microRNA (miRNA) are single-stranded RNA molecules (21-23 nucleotides in length) that regulate gene expression. Regulation is accomplished though annealing of the miRNA to the target strand to block protein translation, although in some cases this initiates mRNA degradation through a process similar to RNA interference (RNAi). miRNA often regulate multiple genes and are thus thought to be able to regulate gene systems. In addition, dysregulation of miRNA has been implicated in diseass, such as cancer and heart disease.

How to pronounce microrna?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say microrna in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of microrna in Chaldean Numerology is: 7

2. Pythagorean Numerology

   The numerical value of microrna in Pythagorean Numerology is: 1

Examples of microrna in a Sentence

1. Alexander Stegh:

   Our approach to gene silencing has not been demonstrated before in such a powerful way for the treatment of brain cancers, these particles, microRNA-based SNAs, could also potentially be used for gene silencing in other cancers and diseases of genetic origin.

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Microrna
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Microrna
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=microrna