Definitions for methotrexate
ˌmɛθ oʊˈtrɛk seɪtmethotrex·ate

Princeton's WordNetRate this definition:0.0 / 0 votes

1. methotrexate, methotrexate sodium, amethopterinnoun

   toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis

WiktionaryRate this definition:0.0 / 0 votes

1. methotrexatenoun

   An antimetabolite and antifolate drug used in treatment of cancer and autoimmune diseases.

WikipediaRate this definition:0.0 / 0 votes

1. Methotrexate

   Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. It is used to treat cancer, autoimmune diseases, and ectopic pregnancies. Types of cancers it is used for include breast cancer, leukemia, lung cancer, lymphoma, gestational trophoblastic disease, and osteosarcoma. Types of autoimmune diseases it is used for include psoriasis, rheumatoid arthritis, and Crohn's disease. It can be given by mouth or by injection.Common side effects include nausea, feeling tired, fever, increased risk of infection, low white blood cell counts, and breakdown of the skin inside the mouth. Other side effects may include liver disease, lung disease, lymphoma, and severe skin rashes. People on long-term treatment should be regularly checked for side effects. It is not safe during breastfeeding. In those with kidney problems, lower doses may be needed. It acts by blocking the body's use of folic acid.Methotrexate was first made in 1947 and initially was used to treat cancer, as it was less toxic than the then current treatments. In 1956 it provided the first cures of a metastatic cancer. It is on the World Health Organization's List of Essential Medicines. Methotrexate is available as a generic medication. In 2020, it was the 113th most commonly prescribed medication in the United States, with more than 5 million prescriptions.

ChatGPTRate this definition:0.0 / 0 votes

1. methotrexate

   Methotrexate is a medication used in treating certain types of cancer and other serious health disorders like severe psoriasis, rheumatoid arthritis, and Crohn's disease. It belongs to a class of drugs known as antimetabolites, and it works by slowing the growth of cancer cells and suppressing the immune system. This drug can also be used in combination with other medications to treat certain types of lung cancer or to control severe, disabling psoriasis that is not responsive to other treatments.

WikidataRate this definition:0.0 / 0 votes

1. Methotrexate

   Methotrexate, abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate began to replace the more toxic antifolate aminopterin starting in the 1950s. The drug was developed by Yellapragada Subbarao.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Methotrexate

   An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

Matched Categories

1. • Antimetabolite
   • Immunosuppressant

How to pronounce methotrexate?

1. Alex

   US English

   David

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   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

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   Fred

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   Tessa

   South African

How to say methotrexate in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of methotrexate in Chaldean Numerology is: 6

2. Pythagorean Numerology

   The numerical value of methotrexate in Pythagorean Numerology is: 1

Popularity rank by frequency of use

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=methotrexate
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Methotrexate
3. ^ Wikipedia
   https://en.wikipedia.org/wiki/Methotrexate
4. ^ ChatGPT
   https://chat.openai.com
5. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=methotrexate