What does machado-joseph disease mean?

Definitions for machado-joseph disease

Here are all the possible meanings and translations of the word machado-joseph disease.

U.S. National Library of Medicine

  1. Machado-Joseph Disease

    A dominantly-inherited ATAXIA first described in people of Azorean and Portuguese descent, and subsequently identified in Brazil, Japan, China, and Australia. This disorder is classified as one of the SPINOCEREBELLAR ATAXIAS (Type 3) and has been associated with a mutation of the MJD1 gene on chromosome 14. Clinical features include progressive ataxia, DYSARTHRIA, postural instability, nystagmus, eyelid retraction, and facial FASCICULATIONS. DYSTONIA is prominent in younger patients (referred to as Type I Machado-Joseph Disease). Type II features ataxia and ocular signs; Type III features MUSCULAR ATROPHY and a sensorimotor neuropathy; and Type IV features extrapyramidal signs combined with a sensorimotor neuropathy. (From Clin Neurosci 1995;3(1):17-22; Ann Neurol 1998 Mar;43(3):288-96)


  1. Chaldean Numerology

    The numerical value of machado-joseph disease in Chaldean Numerology is: 4

  2. Pythagorean Numerology

    The numerical value of machado-joseph disease in Pythagorean Numerology is: 9

Images & Illustrations of machado-joseph disease

  1. machado-joseph diseasemachado-joseph diseasemachado-joseph disease


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