What does loss of heterozygosity mean?
Definitions for loss of heterozygosity
loss of het·erozy·gos·i·ty
This dictionary definitions page includes all the possible meanings, example usage and translations of the word loss of heterozygosity.
Wikidata
Loss of heterozygosity
Loss of heterozygosity. Most diploid cells, for example human somatic cells, contain two copies of the genome, one from each parent; each copy contains approximately 3 billion bases. For the majority of positions in the genome the base present is consistent between individuals, however a small percentage may contain different bases and these positions are called ‘single nucleotide polymorphisms’ or ‘SNPs’. When the genomic copies derived from each parent have different bases for these polymorphic regions the region is said to be heterozygous. The majority of the genome within somatic cells of individuals are heterozygous. However, one parental copy of a region can sometimes be lost, resulting in the region lacking differences at these polymorphic loci and therefore showing loss of heterozygosity. Loss of heterozygosity due to loss of one parental copy in a region is also called hemizygosity in that region.
U.S. National Library of Medicine
Loss of Heterozygosity
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal hemizygosity. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted. When this occurs at a tumor suppressor gene locus where one of the alleles is already abnormal, it can result in neoplastic transformation (CELL TRANSFORMATION, NEOPLASTIC).
Numerology
Chaldean Numerology
The numerical value of loss of heterozygosity in Chaldean Numerology is: 5
Pythagorean Numerology
The numerical value of loss of heterozygosity in Pythagorean Numerology is: 6
Translations for loss of heterozygosity
From our Multilingual Translation Dictionary
- فقدان تغايرArabic
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"loss of heterozygosity." Definitions.net. STANDS4 LLC, 2024. Web. 19 Apr. 2024. <https://www.definitions.net/definition/loss+of+heterozygosity>.
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